• 专利标题:   Improving the stability and bioavailability of egg white angiotensin converting enzyme inhibitory peptide, comprises ultrasonically processing graphene oxide with water, and magnetically stirring mixed solution of manganese chloride.
  • 专利号:   CN112439050-A
  • 发明人:   YU Z, GUO H, ZHAO W, JI H, LI J
  • 专利权人:   UNIV BOGHAI
  • 国际专利分类:   A61K038/08, A61K047/02, A61K009/19, A61P009/12, C01G045/02
  • 专利详细信息:   CN112439050-A 05 Mar 2021 A61K-038/08 202128 Pages: 12 Chinese
  • 申请详细信息:   CN112439050-A CN11396989 01 Dec 2020
  • 优先权号:   CN11396989

▎ 摘  要

NOVELTY - Improving the stability and bioavailability of egg white angiotensin converting enzyme (ACE) inhibitory peptide, comprises (a) adding graphene oxide to water, ultrasonically processing, then adding manganese chloride to obtain mixed solution of manganese(II) ion and graphene oxide; (b) magnetically stirring the mixed solution for a specific period of time, vacuum filtering, and dryingto obtain manganese(II) ion attached graphene oxide sheet, and heating the manganese(II) ion-attached graphene oxide sheets to obtain porous trimanganese tetroxide; and (c) adding the porous trimanganese tetraoxide into water, ultrasonically dispersing, adding active peptide to react for a specific period of time to obtain the reaction liquid, centrifuging the reaction liquid, and freeze-drying to obtain trimanganese tetroxide-active peptide composite powder. USE - The method is useful for improving the stability and bioavailability of egg white angiotensin converting enzyme inhibitory peptide. ADVANTAGE - The method improves the stability and bioavailability of the egg white ACE inhibitory peptide, overcomes its instability in the gastrointestinal tract, and has wide application prospects.