▎ 摘　　要

NOVELTY - Magnetic graphene nano-composite gel, which is obtained by ultrasonic mixing of magnetic graphene nanocomposite and viscoelastic agent, where the concentration of magnetic graphene nanocomposite in the magnetic graphene nanocomposite gel is 1.25-3.5 mg/ml, is claimed. USE - The gel is useful in preparing magnetic therapy material for targeting, inhibiting and treating corneal pathological changes comprising corneal endothelial inflammation, bacterial corneal ulcer, fungal keratitis, punctate keratitis and/or marginal corneal ulcer (all claimed). ADVANTAGE - The gel: inhibits the expression of corneal endothelial inflammation-related factors through low-intensity (less than 30 mT) remote magnetic field suppression technology; greatly improves targeting and effectiveness of magnetic inhibition; efficiently eliminates reactive oxygen species (ROS) in inflammatory cell models; inhibits the expression of inflammatory factors and regulates and controls the development of corneal endothelial inflammation from the molecular level; and provides a new strategy for the treatment of clinical corneal inflammation-related diseases. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: preparing the magnetic graphene nanocomposite gel, comprising (i) preparing magnetic graphene nanocomposites by mixing graphite powder and the carboxylated polymer, then ball-milling at room temperature, and depositing the magnetic nanoparticles on the graphene nanosheets by a co-precipitation method to obtain a magnetic graphene nanocomposite, and (ii) preparing magnetic graphene nanocomposite gel by ultrasonically mixing the synthesized magnetic graphene nanocomposite and sodium hyaluronate viscoelastic to obtain finished product; and a method for targeting and inhibiting corneal pathological changes, comprising introducing the injectable magnetic graphene nanocomposite gel into the corneal endothelium, and then applying a weak magnetic field of 10-30 mT to complete the process.