• 专利标题:   Photo-sensitive active ingredient release scaffold used for preventing or treating hyperglycemia, comprises drug reservoirs comprising photothermal component, first polymer-lipid mixture, and active ingredient, and heat insulating portion.
  • 专利号:   KR2022142946-A
  • 发明人:   OH Y K, KIM D Y, OH Y N
  • 专利权人:   UNIV SEOUL NAT R DB FOUND
  • 国际专利分类:   A61K038/28, A61K041/00, A61K047/34, A61K009/00
  • 专利详细信息:   KR2022142946-A 24 Oct 2022 A61K-041/00 202200 Pages: 41
  • 申请详细信息:   KR2022142946-A KR045996 13 Apr 2022
  • 优先权号:   KR048593

▎ 摘  要

NOVELTY - Photo-sensitive active ingredient release scaffold comprises (i) several drug reservoirs comprising a photothermal component, a first polymer-lipid mixture, and an active ingredient, and (ii) a heat insulating portion comprising a second polymer, where the drug reservoirs are partitioned from each other in the scaffold by the heat insulating portion. USE - The photo-sensitive active ingredient release scaffold is useful in composition for delivering active ingredient, and pharmaceutical composition for preventing or treating hyperglycemia. The hyperglycemia is at least one chosen from type 1 diabetes mellitus, type 2 diabetes mellitus, and gestational diabetes (all claimed). The scaffold is used for lowering blood glucose level. ADVANTAGE - The photosensitive scaffold provides an effective photothermal effect and active ingredient release function in response to photostimulation even when implanted in the body, and achieves repeated insulin release, and thus exhibits repeated blood glucose lowering effect by periodic photostimulation. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: pharmaceutical composition comprising the photo-sensitive active ingredient release scaffold as an active ingredient, where the active ingredient of the photo-sensitive active ingredient release scaffold is at least one chosen from hypoglycemic agent and insulin; and method for preparing the photo-sensitive active ingredient release scaffold involves (a) outputting a heat insulating portion by 3-dimensional (3D) printing, and (b) outputting the drug reservoirs in compartment by 3D printing, where the inside of the scaffold is partitioned by the output heat insulating portion.