• 专利标题:   Making sensory platform used for electrochemical detection of epidermal growth factor receptor in brain tumors by interacting functionalized graphene oxide modified electrode with e.g. epidermal growth factor receptor antibodies.
  • 专利号:   RO135085-A0, RO135085-B1
  • 发明人:   DINESCU M, UDRESCU A, BAIBARAC M, FEJER S
  • 专利权人:   INST NAT CERCETARE DEZV FIZICA MATERIALE, PROVITAM SRL
  • 国际专利分类:   G01N027/327
  • 专利详细信息:   RO135085-A0 30 Jun 2021 G01N-027/327 202161 Pages: 1 English
  • 申请详细信息:   RO135085-A0 RO000735 16 Nov 2020
  • 优先权号:   RO000735

▎ 摘  要

NOVELTY - Process of making a sensory platform involves performing chemical interaction of a screen-printed electrode modified with graphene oxide (GO), electrochemically functionalized with poly(5-amino-1-naphthol) (GO-P5A1N) with 1,4-phenylene diisothiocyanate (PDITC), and then interaction of the GO-P5A1N-PDITC reaction product with G protein leading to covalent attachment to the surface of the modified electrode and then the interaction of the modified electrode with GO-P5A1N-PDITC-G protein with epidermal growth factor receptor (EGFR) antibodies resulting in an assembled structure of sensory platform. USE - The process is useful for making a sensory platform which is useful for electrochemical detection of EGFR in brain tumors.