▎ 摘　　要

NOVELTY - Three-dimensional printed, personalized auricular multipoint bio-signal acquisition, heath status monitoring, and bio-stimulation device comprises an artificial ear model configured to be complementary morphologically to a wearer's outer ear comprising a multiple of 3D printable materials forming a body prepared according to multiple geometrically pre- marked and pre-sampled point locations by 3D scanning, and sensing and simulating electrodes by 3D printing with a multiple of bio-signal sensing ends that are exposed on a surface of the artificial ear model that is proximal to a surface of the wearer's outer ear where the majority of auricular points of human body is located; data acquisition unit for independently and simultaneously collecting real-time bio-signals detected by the multiple of sensing and stimulating electrodes from the multiple auricular points of the wearer's outer ear and processed by an automatic 3D contour mapping user interface. USE - Three-dimensional printed, personalized auricular multipoint bio-signal acquisition, heath status monitoring, and bio-stimulation device for making the device by 3-D printing, for diagnosing and/or monitoring health status of a subject. ADVANTAGE - The three-dimensional printed, personalized auricular multipoint bio-signal acquisition, heath status monitoring, and bio-stimulation device is reliable, repeatable, personalized device with quantitative measurement and visualization capabilities of bio-signals from human auricle, achieves multi-point bio-signals acquisition and stimulation across the entire auricle for healthcare applications. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a method for making the device which comprises: a. providing a reverse auricular mold comprising preparing a three-dimensional artificial ear body by 3D molding to have an ear impression shaping conformably with human auricle, mixing at least one bio-compatible polymer with catalyzer uniformly to obtain a mixture, and filling up the three-dimensional artificial ear body with the mixture until the mixture is solidified in order to form a body of the reverse auricular mold; b. scanning a three-dimensional geometry of the human auricle comprising using a structural-light-based three-dimensional scanning to generate a point cloud for subsequent three-dimensional geometrical configuration of the reverse auricular mold; c. subjecting the reverse auricular mold simultaneously to a 3D printing device incorporating at least a flexible elastomer and a conductive material to generate one or more sensing and stimulating electrodes with a sensing end of each of the one or more electrodes that is exposed at the surface which is proximal to the surface of the wearer's outer ear where the majority of the auricular points is located such that a mechanically stable while flexible electrode-human skin interface is formed; and (2) a method for diagnosing and/or monitoring health status of a subject which comprises: a. providing the device to the subject by physically or non-physically contacting a surface of a body of the device with a surface of an outer ear of the subject, the surface of the body of the device which is in physical or non-physical contact with the surface of the outer ear of the subject comprising a multiple of sensing ends of multiple sensing and stimulating electrodes and interconnecting with a multiple of interconnections disposed at an opposite side to the surface of the body of the device, the surface of the body of the device forming a mechanically stable while flexible electrode-skin interface with the surface of the outer ear of the subject where the majority of auricular points is located in order to receive real-time bio-signals from the surface of the outer ear of the subject and respond to the received bio-signals after is processed and subsequently analyzed by an automatic 3D contour user interface.