▎ 摘　　要

NOVELTY - Detecting at least one analytes associated with a disease or condition in a subject suspected to have the disease or condition, comprises measuring the resistance of a device that has been or is in contact with a sample obtained from the subject, the device comprises at least one layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer that is selective for the at least one analytes associated with the disease or condition in electrical communication with the at least one layers of metal, where the at least one layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or its an alloy, and the device has an inherent resistance, and a difference between the inherent resistance of the device and the resistance of the device contacted with the sample indicates at least one analytes associated with the disease or condition have been detected. USE - The method is useful: for detecting analytes associated with a disease or condition in a subject suspected to have the disease or condition, where the disease or condition is alzheimer's disease, lung cancer; and for diagnosing a disease or condition in a subject suspected to have the disease or condition, or at risk for developing the disease or condition (all claimed). ADVANTAGE - The method which as devices have been demonstrated to show sensitivity of from 20-100 parts per trillion, to be highly selective, and to be capable of differentiating between transgenic human APE4 knock-in rats with AD and healthy controls.