▎ 摘　　要

NOVELTY - The biosensor has a first and second substrates (1,2,10) defining a cavity between the substrates. A sensing structure has a functionalized active surface (4) provided on the first substrate within cavity. A flow control structure is provided on second substrate and extended into cavity where a gap between the distal end of the flow control structure (11) and sensing structure provides a fluid flow channel across functionalized active surface. The flow control structure is shaped and configured such that fluid dropped/injected at the inlet port (15a) flows into and through the fluid flow channel to the outlet port (15b), so that a shear force is exerted on active surface. The second substrate is a solid dielectric substrate. The flow control structure has a polymer. The first structure has any biocompatible polymer. USE - Graphene-based biosensor of biosensor device (claimed) for detecting biological molecules in a biological specimen collected from a patient. Uses include but are not limited to proteins, polysaccharides, nucleic acids, primary metabolites, secondary metabolites, and natural products. ADVANTAGE - The biosensor has a patterned and chemically functionalized graphene surface. The graphene-based biosensor has versatility and sensitivity for sensing a wide variety of different biological molecules or analytes, depending on the functionalization of the graphene surface and the electrical measurement used to sense and quantifies them. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: a biosensor device; and a method of fabricating a biosensor. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic cross-sectional view of a single biosensor. 1,2,10First substrate 4Functionalized active surface 11Flow control structure 15aInlet port 15bOutlet port