• 专利标题:   Carrier for anionic material for photothermal therapy and used in life sciences such as drug delivery, photothermal therapy, in which hydrophilic polymer and cationic polymer are chemically bonded to reduced graphene oxide.
  • 专利号:   KR2018065473-A, KR1967660-B1
  • 发明人:   IN T H, CHAN H J, JUNHWA S, JOON Y S, TAE H I, HEE J C, YONG S J
  • 专利权人:   KOREA ATOMIC ENERGY RES INST
  • 国际专利分类:   A61K047/02, A61K041/00, A61K047/30, A61K047/48, A61K048/00, C01B031/04
  • 专利详细信息:   KR2018065473-A 18 Jun 2018 A61K-047/02 201852 Pages: 17
  • 申请详细信息:   KR2018065473-A KR166396 08 Dec 2016
  • 优先权号:   KR166396

▎ 摘  要

NOVELTY - Carrier in which hydrophilic polymer and a cationic polymer are chemically bonded to a reduced graphene oxide (rGO). USE - Carrier for anionic material and intracellular gene delivery system for photothermal therapy (all claimed) and used in life sciences such as drug delivery, cell imaging, photothermal therapy, biosensors, tissue engineering, gene / protein expression and cell signaling basic studies. ADVANTAGE - The carrier uses no harmful toxic reducing agent, and thus is suitable for cell-based biological research, saves energy and is applied in simple, fast and environmentally friendly process. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a method for preparing carrier, which involves preparing an aqueous solution containing graphene oxide (GO); adding hydrophilic polymer having a terminal functional group capable of forming a bond with a carboxyl group and a cationic polymer to the aqueous solution containing the oxidized graphene (GO); bonding the carboxyl group present in the graphene oxide to the hydrophilic polymer and the cationic polymer; irradiating the graft oxide (GO) chemically bonded to the hydrophilic polymer and the cationic polymer with radiation; bonding the hydrophilic polymer and the cationic polymer to the reduced graphene oxide (rGO); (2) a intracellular gene delivery system, which comprises cationic polymer and the anionic gene of the carrier bound by ionic bonding; (3) a method for preparing intracellular gene delivery system, which involves preparing an aqueous solution containing graphene oxide (GO); adding hydrophilic polymer having a terminal functional group capable of forming a bond with a carboxyl group and a cationic polymer to the aqueous solution containing the oxidized graphene (GO); bonding the carboxyl group present in the graphene oxide to the hydrophilic polymer and the cationic polymer; bonding graft oxide (GO) chemically to the hydrophilic polymer and the cationic polymer and irradiating with radiation; bonding the hydrophilic polymer and the cationic polymer to the reduced graphene oxide (rGO); and (4) bonding hydrophilic polymer and the cationic polymer chemically and mixing with reduced graphene oxide (rGO) and an anionic gene to form an ionic bond between the cationic polymer and the anionic gene.