▎ 摘　　要

NOVELTY - Dry graphene solid is dissolved in ultrapure water and ultrasonically processed, to obtain uniformly-dispersed fused graphene solution. A solution of 1-ethyl-(3-dimethylaminopropyl)carbodiimide is dripped to graphene oxide solution and reacted. Nitrogen-hydroxysuccinic acid imine solution is added to graphene solution, stirred and reacted, to obtain activated carbonized graphene solution. The activated carbonized graphene solution is dripped to chitosan solution, stirred, added to mold and freeze-dried, to obtain crosslinked oxidized graphene-chitosan composite material. USE - Preparation of oxidized graphene-chitosan composite material used for bone treatment. ADVANTAGE - The method enables preparation of oxidized graphene-chitosan composite material having excellent mechanical property and interface bonding characteristics. DETAILED DESCRIPTION - Chitosan solid powder is placed in oven, dried and sieved to remove impurities. 2 vol.% Acetic acid solution is added to mixture, to obtain 1-3 %mass chitosan solution. Dry graphene solid is weighed and dissolved in ultrapure water and ultrasonically processed for 1-3 hours, to obtain 1-3 %mass uniformly-dispersed fused graphene solution. A solution of 1-ethyl-(3-dimethylaminopropyl)carbodiimide with concentration of 0.01-0.05 mmol/L is dripped to graphene oxide solution with stirring and reacted for 10-15 minutes. Nitrogen-hydroxysuccinic acid imine solution with concentration of 0.02-0.08 mmol/L is added to graphene solution, stirred and reacted for 1-3 hours, to obtain activated carbonized graphene solution. The activated carbonized graphene solution is dripped to chitosan solution, stirred at 40-80 degrees C for 10-50 minutes, cooled to room temperature, added to mold and freeze-dried, to obtain crosslinked oxidized graphene-chitosan composite material.