▎ 摘　　要

NOVELTY - Preparing antibody-coupled graphene oxide involves performing biological coupling of human monoclonal antibodies (mAbs) and graphene oxide through the linking agent 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to prepare a coupling complex, adding polyethylene glycol to the coupling complex, and passing through the same linking agent 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and the ester bond formed between polyethylene glycol and graphene oxide in the coupling complex. Polyethylene glycol is coupled to graphene oxide to prepare PEGylated antibody coupled to graphene oxide PEGs-ACGO. USE - Method for preparing antibody-coupled graphene oxide. ADVANTAGE - The method enables to prepare antibody-coupled graphene oxide, which targets HIV surface antigen and induces local heating through external stimulation and is injected intravenously to enhance the biodistribution of the complex, thus increasing the binding success rate. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for use of antibody coupled graphene oxide is claimed for eliminating the infected cells and the HIV virus, where PEGylated antibody coupled to graphene oxide PEGs-ACGO is irradiated in stages with equal time intervals (30 seconds) under near-infrared light as required to induce local heating and temperature of the target location related to the HIV virus is increased by external stimulation, thus eliminating the infected cells and the HIV virus.