▎ 摘　　要

NOVELTY - Nanogap sensor (100) comprises: a micropore layer (120) comprising a micropore (120); a graphene sheet (130) disposed on the micropore layer and comprising a nanoelectrode region (134), where the nanoelectrode region comprises a nanogap (135) aligned with the micropore; a first electrode disposed on the graphene sheet; and a second electrode disposed on the graphene sheet, where the first electrode and the second electrode are connected to the nanoelectrode region at opposite ends of the nanoelectrode region relative to the nanogap. USE - The nanogap sensor is useful in a device for detecting a biomolecule in a sample, where the sample comprises DNA or RNA (all claimed) or proteins. ADVANTAGE - The nanogap sensors: is easily manufactured by utilizing graphene sheet; and provides improved detection of biomolecule when compared to conventional techniques since the nanogap is implemented using the graphene sheet, the length of the nanogap through which target biomolecules pass is very small, thus improving that resolution of target molecules detection. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) a device comprising: the nanogap sensor positioned in a water tank for accommodating a sample, where the sample contains a biomolecule that can pass through the nanogap of the nanogap sensor; and a power supply unit configured to provide an electric field in the water tank such that biomolecules in the sample will move in the water tank; (2) a method of detecting a biomolecule in a sample, comprising either: contacting the nanogap sensor with a sample, and detecting a change in voltage or a tunneling current between the first and second electrodes, where detection of a change in voltage or a tunneling current between the first and second electrodes indicates the presence of a biomolecule in the sample; or introducing a sample into the water tank of the device, applying a voltage to the third and fourth electrodes, and detecting a change in voltage or a tunneling current between the first and second electrodes, where detection of a change in voltage or a tunneling current between the first and second electrodes indicates the presence of a biomolecule in the sample; and (3) manufacturing a nanogap sensor, comprising: forming a micropore layer on a substrate, where the micropore layer comprises an insulating material; forming a nanoelectrode on the micropore layer, where the nanoelectrode comprises graphene; forming a micropore in the micropore layer, where the micropore perforates the micropore layer; and forming a nanogap in the nanoelectrode, where the nanogap perforates the nanoelectrode and is aligned with the micropore. DESCRIPTION OF DRAWING(S) - The figure shows cross-sectional views illustrating a method of manufacturing a nanogap sensor. Nanogap sensor (100) Micropore layer (120) Graphene sheet (130) Nanoelectrode region (134) Nanogap (135)