• 专利标题:   Ferrous-ferric oxide-polyethylene glycol-graphene oxide/doxorubicin nano-composite material useful as anti-tumor medicinal carrier in tumor-magnetic target, T2 mode imaging and chemotherapy.
  • 专利号:   CN104815337-A
  • 发明人:   CHEN W, ZHEN G, ZHENG X
  • 专利权人:   UNIV LINYI
  • 国际专利分类:   A61K031/704, A61K047/04, A61K047/48, A61K049/08, A61K009/14, A61P035/00
  • 专利详细信息:   CN104815337-A 05 Aug 2015 A61K-047/48 201609 Pages: 11 Chinese
  • 申请详细信息:   CN104815337-A CN10242930 14 May 2015
  • 优先权号:   CN10242930

▎ 摘  要

NOVELTY - Ferrous-ferric oxide-polyethylene glycol-graphene oxide/doxorubicin nano-composite material, is claimed. The preparation of graphene oxide-polyethylene glycol comprises bonding the surface of graphene oxide with aminated polyethylene glycol derivative by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide to increase its water solubility. USE - The ferrous-ferric oxide-polyethylene glycol-graphene oxide/doxorubicin nano-composite material is useful as anti-tumor medicinal carrier in tumor-magnetic target, T2 mode imaging and chemotherapy (claimed). ADVANTAGE - The nano-composite material is suitable for other anticancer drug tumor treatment along with magnetic resonance imaging to obtain therapeutic effect. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing ferrous-ferric oxide-polyethylene glycol-graphene oxide/doxorubicin nano-composite material, comprising adding ferrous-ferric oxide magnetic nano-particles (10 nm)-containing n-hexane solution into meso-2,3-dimercaptosuccinic acid-containing acetone solution, stirring at 60 degrees C for 4 hours, adding 2 volumes of ethanol, ultrasonicating for 30 minutes, carrying out magnetic separation, removing supernatant by retaining the precipitate, repeating the process for two times.