▎ 摘　　要

NOVELTY - An antitumor medicine comprises a small interfering RNA (siRNA) targeting solute carrier family 7 member 11 (SLC7A11) gene. USE - The antitumor drug-loading nanomaterial complex is useful in preparing antitumor medicine for liver cancer or pancreatic cancer (claimed). ADVANTAGE - The antitumor drug-loaded nanomaterial complex has good dispersibility, solves the problems of toxic side effects and drug resistance brought by the traditional chemotherapy drugs, belongs to nano drugs that preferentially target cancer cells through ferroptosis, which can significantly improve efficiency of antitumor therapy in vitro and in vivo, and is a very promising strategy for tumor-targeted therapy. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: an antitumor drug-loaded nanomaterial complex comprising a graphene oxide carrier, which is modified by SP94-polyethylene glycol (SP94-PEG), and the antitumor medicine; and a preparation method of the antitumor drug-loaded nanomaterial complex comprising (S1) mixing graphene oxide powder with alpha, omega-bis-amino poly(ethylene glycol) (HN-PEG-NH), adding 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide to the mixture, stirring at a low temperature, and centrifuging to collect dark brown precipitate, (S2) dispersing the dark brown precipitate using a solvent, adding EDC and N-hydroxysuccinimide to the suspension, stirring, adding SP94 short peptide powder, continuously stirring at a low temperature, and centrifuging to obtain graphene oxide connected with SP 94-PEG, (S3) dispersing the graphene oxide connected with SP 94-PEG using a solvent, adding branched polyethylenimine and EDC to the suspension, stirring, adding doxorubicin-ferrous ion and sorafenib, sonicating at a low temperature, stirring, collecting the precipitate after centrifugation, and freeze-drying to obtain the freeze-dried precipitate, and (S4) dispersing the freeze-dried precipitate using a solvent, adding siRNA, and uniformly mixing to obtain the product.22