• 专利标题:   Modified reduced graphene oxide microfine fiber used in neural tissue scaffold for directional induced neural differentiation of bone marrow mesenchymal stem cell, comprises reduced graphene oxide and conductive macromolecule polymer.
  • 专利号:   CN106592007-A, CN106592007-B
  • 发明人:   GUO W, LIU H
  • 专利权人:   BEIJING NANOENERGY NANOSYSTEMS INST
  • 国际专利分类:   A61L027/08, A61L027/18, D01F001/09, D01F006/94
  • 专利详细信息:   CN106592007-A 26 Apr 2017 D01F-006/94 201744 Pages: 14 Chinese
  • 申请详细信息:   CN106592007-A CN10282724 29 Apr 2016
  • 优先权号:   CN10282724

▎ 摘  要

NOVELTY - Modified reduced graphene oxide microfine fiber comprises reduced graphene oxide and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT) as conductive macromolecule polymer, where microfine fiber is continuous, and has regular porous nano-structure on its surface. USE - Modified reduced graphene oxide microfine fiber used in neural tissue scaffold for directional induced neural differentiation of bone marrow mesenchymal stem cell, and used in self-driven nerve repair system for generating powder for promoting bone marrow mesenchymal stem cell differentiation to nerve (all claimed). ADVANTAGE - The modified reduced graphene oxide microfine fiber has good shape, surface appearance and conductivity, and has good adhesion and proliferation ability to bone marrow mesenchymal stem cell. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a method for preparing modified reduced graphene oxide microfine fiber, which involves carrying out heat treatment of a mixed solution containing graphene and PEDOT at high temperature; (2) a neural tissue scaffold, which comprises modified reduced graphene oxide microfine fiber; and (3) a self-driven nerve repair system, which comprises neural tissue scaffold and self-driven separate friction nano generator, where neural tissue scaffold and separated friction generator generates power for promoting differentiation of bone marrow mesenchymal stem cell into neurons.