• 专利标题:   Preparing high strength antibacterial nano fiber membrane comprises e.g. obtaining oxidized graphene modified polyvinyl alcohol, silver ion aptamer modified carboxymethyl cellulose, and static spinning solution, and electrostatic spinning.
  • 专利号:   CN108456998-A
  • 发明人:   SHI M
  • 专利权人:   SUZHOU FUZHONG PLASTIC CO LTD
  • 国际专利分类:   D04H001/728, D01D005/00
  • 专利详细信息:   CN108456998-A 28 Aug 2018 D04H-001/728 201866 Pages: 10 Chinese
  • 申请详细信息:   CN108456998-A CN10177721 05 Mar 2018
  • 优先权号:   CN10177721

▎ 摘  要

NOVELTY - Preparing high strength antibacterial nano fiber membrane comprises e.g. (i) obtaining oxidized graphene modified polyvinyl alcohol, (ii) adding carboxymethyl cellulose and succinic acid to dimethylformamide solution, reacting under stirring state, collecting upper organic layer by extracting using ethyl acetate, drying, collecting product, dissolving product in aqueous solution, adding N-hydroxysuccinimide, adding silver ion adaptor DNA1 and carbodiimide, carrying out ultra filtration, reacting, and collecting interception product to obtain silver ion aptamer modified carboxymethyl cellulose, (iii) adding polyvinyl alcohol, silver ion aptamer modified carboxymethyl cellulose, polycaprolactone, silver ion adaptor DNA2, silver nitrate, polyvinylpyrrolidone, and fibroin into mixed solvent, adding polyphthalamide, lauryl alcohol ester, polyacrylate, chlorotrifluoroethylene, methylisothiazolinone, and dodecyl trimethyl ammonium chloride, and performing ultrasonic treatment. USE - The method is useful for preparing high strength antibacterial nano fiber membrane. DETAILED DESCRIPTION - Preparing high strength antibacterial nano fiber membrane comprises (i) adding 100 pts. wt. graphene oxide to 5-10 pts. wt. dimethylformamide solution containing 10-20 wt.% silane coupling agent, stirring and reacting at 75-80 degrees C for 5-10 hours, removing upper solvent to collect lower particle deposition, resuspending in dimethylformamide solution to a mass fraction of 30-50% by centrifugation, carrying out ultrasonic treatment in an ultrasonic instrument for 20-40 minutes, adding 30-80 pts. wt. polyvinyl alcohol under stirring condition, and continuously reacting at 40-60 degrees C for 2-4 hours to obtain oxidized graphene modified polyvinyl alcohol, (ii) adding 100 pts. wt. carboxymethyl cellulose and 30-50 pts. wt. succinic acid to 10-20 pts. wt. dimethylformamide solution, reacting under stirring state at 40-60 degrees C for 12-24 hours, collecting upper organic layer by extracting using ethyl acetate, drying using rotating evaporator, collecting product, dissolving the product in 5-10 times of aqueous solution, adding 5-20 pts. wt. N-hydroxysuccinimide under stirring condition, stirring at room temperature reaction for 20-30 minutes, under the condition of stirring, adding 80-200 pts. wt. silver ion adaptor DNA1 and 40-60 pts. wt. carbodiimide, carrying out ultra filtration using ultra filtration pipe of 1000 molecular weight cut-off, continuously reacting for 5-8 hours, and collecting interception product to obtain silver ion aptamer modified carboxymethyl cellulose, where aptamer DNA1 is 5'-NH2- aaaaactctctctctctctctctctc-3', (iii) adding 30-60 pts. wt. polyvinyl alcohol, 20-40 pts. wt. silver ion aptamer modified carboxymethyl cellulose, 15-30 pts. wt. polycaprolactone, 50-80 pts. wt. silver ion adaptor DNA2, 5-12 pts. wt. silver nitrate, 4-8 pts. wt. polyvinylpyrrolidone, and 8-15 pts. wt. fibroin into 5-10 times of mixed solvent, stirring until the solution becomes dark red at 28-35 degrees C and does not change, adding 3-8 pts. wt. polyphthalamide, 5-10 pts. wt. lauryl alcohol ester, 5-9 pts. wt. polyacrylate, 3-7 pts. wt. chlorotrifluoroethylene, 6-12 pts. wt. methylisothiazolinone, and 4-9 pts. wt. dodecyl trimethyl ammonium chloride, continuously stirring for 2-4 hours, and performing ultrasonic treatment for 20-50 minutes to obtain static spinning solution, where the aptamer DNA2 is: 5'-cacacacacacacacacacac-3', and (iv) electrostatic spinning the resultant solution, and receiving nanowires to obtain high strength antibacterial nano fiber film, where the electrostatic spinning technique parameters are as follows: the voltage is 25-50 KV, receiving distance is 10-20 cm, the spinning hole diameter is 0.2-1 mm, and the spinning speed is 30-60 mu l/min. AN INDEPENDENT CLAIM is also included for high strength antibacterial nano fiber membrane prepared by the above mentioned method.