• 专利标题:   Preparing nano drug carrier used for loading drugs and detecting purposes, comprises magnetic graphene and fluorescent quantum dot, where fluorescent quantum dot is uniformly distributed on magnetic graphene.
  • 专利号:   CN105267980-A, CN105267980-B
  • 发明人:   LIU F, SONG Y, SUN K, TANG X, YANG L, DING Y
  • 专利权人:   UNIV JINAN, UNIV JINAN
  • 国际专利分类:   A61K031/513, A61K031/704, A61K047/04, A61K047/48, A61K049/00, A61K009/19, A61P035/00, A61K047/52, A61K047/69
  • 专利详细信息:   CN105267980-A 27 Jan 2016 A61K-047/48 201627 Pages: 10 English
  • 申请详细信息:   CN105267980-A CN10805317 20 Nov 2015
  • 优先权号:   CN10805317

▎ 摘  要

NOVELTY - Nano drug carrier comprises magnetic graphene and fluorescent quantum dot, where fluorescent quantum dot is uniformly distributed on magnetic graphene. USE - Method for preparing nano drug carrier used for loading drugs (claimed) and detecting purposes. ADVANTAGE - The method enables to prepare nano drug carrier that ensures increased medicine stability, mild reaction condition, good biological compatibility, controlled release of anti-tumour medicine and wide application prospect. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing nano drug carrier, which involves: (A) dispersing magnetic graphene, iron salt, hexamethylenetetramine and graphite oxide alkene solution in ethanediol solution ultrasonically for 10-90 minutes for 4-12 hours at 150-220 degrees C; (B) separating magnetic graphene using water and anhydrous ethyl alcohol; (C) drying magnetic graphene; (D) dispersing magnetic graphene in distilled water and dispersant ultrasonically for 20-60 minutes uniformly; (E) oscillating obtained mixture with anti-tumor medicine at room temperature for 2-10 hours; (F) washing obtained material; (G) freeze-drying washed material for 48 hours to obtain drug containing compound A; (H) dissolving quantum dot in distilled water using N-hydroxyl succinimide to obtain reaction solution B; (I) mixing medicine containing compound A with distilled water, dispersant and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, ultrasonically for 10-30 minutes to obtain reaction solution C that is mixed with reaction solution B at room temperature for 2-8 hours; and (J) centrifuging obtained mixture to obtain product.