• 专利标题:   Preparing nano-drug controlled release system useful for providing anti-tumor effect, by mixing erythrocyte membrane vesicles with targeting molecules, adding photosensitizing drug-loaded graphene oxide and performing stirring reaction.
  • 专利号:   CN108066317-A
  • 发明人:   NIE X, LI J, GUI R, WANG Y, JIANG H
  • 专利权人:   UNIV CENT SOUTH XIANGYA 3RD HOSPITAL
  • 国际专利分类:   A61K031/704, A61K041/00, A61K047/04, A61K047/22, A61K047/46, A61K009/51, A61P035/00
  • 专利详细信息:   CN108066317-A 25 May 2018 A61K-009/51 201851 Pages: 14 Chinese
  • 申请详细信息:   CN108066317-A CN11377861 19 Dec 2017
  • 优先权号:   CN11377861

▎ 摘  要

NOVELTY - Method for preparing nano-drug controlled release system involves (a) preparing nano-erythrocyte membrane vesicles, (b) preparing photosensitizing drug-loaded graphene oxide, (c) preparing a targeting molecule and (d) mixing the erythrocyte membrane vesicles obtained in step (a) with the targeting molecules obtained in step (c), adding phosphate-buffered saline (PBS), performing stirring reaction to obtain targeted erythrocyte membrane vesicles, mixing the targeted erythrocyte membrane vesicles with the photosensitizing drug-loaded graphene oxide obtained in step (b), ultrasonically treating and again performing stirring reaction to obtain nano-drug controlled release system. USE - The method is useful for preparing nano-drug controlled release system which is useful for providing anti-tumor effect. ADVANTAGE - The method enables preparation of nano-drug controlled release system which has excellent biocompatibility in the human body is non-toxic, hence does not cause side effects or rejection reaction, prevents nanocarriers from being encapsulated to maintain the activity of the targeting molecules, reduces the surface free energy of graphene oxide and increases the dispersibility. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for nano-drug controlled release system, which is prepared as mentioned above.