• 专利标题:   Carrier used for anthracycline-group-based anticancer drug, is provided with anthracycline immobilized on flaky graphene oxide suspended in sol containing enzyme hydrolyzing peptide bond in linker connecting graphene oxide with drug.
  • 专利号:   PL431631-A1, PL241480-B1
  • 发明人:   TRUSEK A, NOWORYTA A
  • 专利权人:   POLITECHNIKA WROCLAWSKA
  • 国际专利分类:   A61K031/704, A61K047/04, A61K047/18, A61K047/65, B82Y005/00, C01B032/182, A61K047/52
  • 专利详细信息:   PL431631-A1 04 May 2021 B82Y-005/00 202149 Pages: 1
  • 申请详细信息:   PL431631-A1 PL431631 28 Oct 2019
  • 优先权号:   PL431631

▎ 摘  要

NOVELTY - A drug carrier is provided with an anthracycline immobilized on a flaky graphene oxide by a peptide linker. The graphene oxide is suspended in a sol containing an enzyme hydrolyzing the peptide bond in the linker connecting the graphene oxide with the drug. USE - Carrier is used for anthracycline-group-based anticancer drug, preferably doxorubicin and epirubicin. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for production of the carrier, which involves adding a solution of divinylsulfone to graphene oxide which activates hydroxyl groups present on a surface of graphene oxide, adding 1-10 mg/L Gly-Gly-Leu peptide linker to the graphene oxide, blocking the groups not occupied with the peptide with ethanolamine, adding a hydroxysulfosuccinimide and carbodiimide solution for activating the carboxyl groups of the linker, adding 5-30 mg/L anthracycline solution, drying the graphene oxide until water is completely removed, suspending the graphene oxide in 0.01-1 mg/L sol containing the enzyme hydrolyzing peptide bonds, and placing inside a thin porous membrane with a cut-off factor of 3-10 kDa.