• 专利标题:   Graphene channel used in biosensor for wearable device, comprises graphene film, and perylene diimide derivative bonded to cortisol aptamer.
  • 专利号:   KR2245960-B1
  • 发明人:   KWONOSUK, PARK S, AHN J E, KIM K H, HA S Y, KIM J, SEONGEUN S
  • 专利权人:   AGENCY DEFENSE DEV, KOREA RES INST BIOSCIENCE BIOTECHNOLOG
  • 国际专利分类:   A61B005/00, A61B005/1477, C07D487/06, G01N033/543, G01N033/74
  • 专利详细信息:   KR2245960-B1 30 Apr 2021 C07D-487/06 202139 Pages: 22
  • 申请详细信息:   KR2245960-B1 KR182172 23 Dec 2020
  • 优先权号:   KR182172

▎ 摘  要

NOVELTY - A graphene channel comprises a graphene film, and a perylene diimide derivative (I), where cortisol aptamer is bonded to the compound (I). USE - Graphene channel used in biosensor for wearable device useful for detecting cortisol in secretion discharged to outside of body (all claimed). ADVANTAGE - The graphene channel has excellent stability to the external environment, binding density with graphene films, and low steric hindrance in binding with bioprobes. DETAILED DESCRIPTION - A graphene film comprises a graphene film, and a perylene diimide derivative of formula (I), where cortisol aptamer is bonded to the compound (I). R1,R2 = H or hydrocarbyl such as 1-10C alkyl, 3-10C aryl, heteroaryl (all optionally substituted with halo, cyano, hydroxy, thio, amido, alkyl, alkoxy, alkylamino, dialkylamino, aryl, aryloxy, arylamino, diarylamino, or heteroaryl). INDEPENDENT CLAIMS are included for the following: (1) a biosensor, which comprises a silk film, and the graphene channel; and (2) a wearable device, which comprises the biosensor.