▎ 摘　　要

NOVELTY - Graphene oxide load type delivery system, is claimed. The insoluble anti-tumor medicine is loaded onto a graphene oxide (GO) sheet by a non-covalent dynamic bonding interaction without chemical reaction and the basic structure of the GO sheet layer is a sheet structure comprises a nano-scale single-layer carbon atoms. USE - The system is useful for preparing a biological medicine (claimed). ADVANTAGE - The system has good solubility in water and has PH-sensitive release, can stabilize the drug in the stomach, is slowly released in the intestinal tract, and achieves a slow and stable release effect, thus avoids side effects caused by rapid excessive absorption of the drug, which can be used to improve clinical drug delivery and good clinical research. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing the graphene oxide load type delivery system comprising (i) mechanically stirring the GO solid, ultrasonically stripping to prepare 50 ml of GO solution having a concentration of carbon monoxide (mg/ml) and placing it in a beaker, dissolving imatinib with a mass of M1 (mg) in methanol to obtain imatinib solution, slowly and drop wisely adding the imatinib solution into the GO solution under stirring at light reaction and continuously stirring to obtain reaction liquid; (ii) adding the reaction liquid into 50 ml centrifuge tube and centrifuging with a high-speed bench-top refrigerated centrifuge, aspirating the supernatant into a large beaker, washing the lower layer with 100 ml methanol and centrifuging again and the centrifugation conditions are the same as above, then repeating washing three times, mixing the supernatants and measuring the volume to obtain volume L1, pipette out 1 ml of the supernatant and filtering it through 0.45 mu m organic filter and transferring it to a high-performance liquid phase injection bottle, sealing the sealing film in a refrigerator at 4 degrees C for storage; and (iii) transferring the precipitate of (ii) into a watch glass, sealing the wrap film and pre-freezing at -80 degrees C for 24 hours, transferring the sample into a lyophilizer and vacuum-drying to obtain the product GO-IM.