▎ 摘　　要

NOVELTY - The device has a cell chamber that accommodates several biological cells arranged within a fluid. The cell chamber is partially enclosed within an immuno-isolative membrane which permits diffusive exchange of nutrients between the fluid and a tissue in which the device is implanted for sustaining several biological cells. The cell chamber is configured to accommodate flow of fluid through the cells. A pump induces convective flow of the fluid within the cell chamber. A conduit is fluidly connected to the cell chamber. The pump is coupled to the cell chamber through the conduit. The immune-isolative membrane partially enclosing the cell chamber comprises a semi-permeable material configured to prohibit transfer of immunocompetent cells or immunoglobin molecules. A hollow fiber is fluidly coupled to the pump and the cell chamber. The hollow fiber comprises a semi-permeable membrane. The hollow fiber extends through the cell chamber. USE - Cell encapsulating implantable device for macro-encapsulation of implanted cells for convective flow of perfusate at time of diabetes treatments. ADVANTAGE - The macroencapsulation of implanted cells which provide convective flow of perfusate in immuno-isolative manner can be realized, so that immune-isolation of transplanted cells can be achieved. DETAILED DESCRIPTION - The semi-permeable membrane of the hollow fiber permits diffusive exchange of nutrients between the fluid and the tissue and prohibits transfer of immunocompetent cells or immunoglobin molecules between the fluid and the tissue. The semi-permeable membrane of the hollow fiber includes a 100 kDa molecular weight cut-off. The pump delivers the fluid to the cell chamber in a unidirectional flow path. The cell chamber comprises an efferent perfusate outlet port. The pump and the cell chamber are fluidly coupled in a closed loop that recirculates the fluid. The hollow fiber comprises an alternate foreign body response (aFBR)-promoting membrane. An equilibrium chamber is arranged adjacent to the cell chamber, and comprises a first equilibration chamber arranged between the pump and the cell chamber. The cell chamber is fabricated by deposition of three-dimensional (3D) printing materials. The hollow fiber is provided as a condensed 3D shape comprising rosette, woven structure, braid, helix, spiral, sinusoid, cylinder, rectangular prism, semi-sphere, dome, tube, ellipsoid, or multi-pointed star. The 3D printing materials include sacrificial and non-sacrificial components. The pump comprises an infusion pump, an insulin pump, a refillable pump, a micro piezoelectric pump, or a modified microperistaltic pump. The biological cells are embedded within the cell chamber in a hydrogel. An INDEPENDENT CLAIM is included for method for fabricating the cell encapsulating implantable device, involves additively applying 3D printing materials. The immuno-isolative membrane is applied to the 3D materials by conformal spray coating. A hollow fiber which extends through the cell chamber is generated. The hollow fiber comprises a semi-permeable surface in communication with several biological cells. The sacrificial material is removed to produce several vacant spaces. Several biological cells are filled into several vacant spaces. Several pancreatic islet cells are present at a density of 2.5 IEQ/pL. The biological cells are embedded within the cell chamber in a hydrogel. The biological cells are loaded into the device pre implantation or post-implantation. The device elutes a drug for treating the disease or condition. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of the scaied-up system for mass production.