▎ 摘　　要

NOVELTY - Nanoparticle with antibody bound to the surface comprises phospholipid membrane in which photothermal nanoparticles are collected, and an antibody or its fragment bound to the surface of the phospholipid membrane, a surface protein of cancer cells. USE - The nanoparticle is useful in pharmaceutical composition for treating cancer chosen from ovarian cancer, stomach cancer, colorectal cancer, prostate cancer, pancreatic cancer, and breast cancer by inducing apoptosis of cancer cells (all claimed). ADVANTAGE - The nanoparticle has a small particle size and excellent stability. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) pharmaceutical composition comprising the above-mentioned nanoparticles; and (2) method for producing phospholipids bound to the surface of an antibody-light-thermal nanoparticles involves (a) mixing a dopamine hydrochloride solution with a sodium hydroxide solution to prepare polydopamine nanoparticles, (b) dissolving phospholipids chosen from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG), phosphorylglycerol (PG), phosphocholine (PC) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(maleimide(polyethyleneglycol)-2000)(DSPE-PEG2000-maleimide) and concentrating under reduced pressure, (c) hydrating by adding the polydopamine nanoparticles to the phospholipid membrane, and (d) adding and stirring an antibody or its fragment capable of binding to a cancer cell surface protein.