▎ 摘　　要

NOVELTY - Extrudable photocrosslinkable hydrogel comprises a biochemically modified extracellular matrix (ECM) with embedded electroconductive nanomaterial; a photoinitiator; and a solvent. USE - The hydrogel is useful for preparing electroconductive scaffolds, electroconductive extrudable hydrogels for in situ defect-filling, conductive grafts, in situ printed tissue or organs, adhesive for different tissues, or bone adhesive (claimed). ADVANTAGE - The hydrogel has photocrosslinking, thermal sensitivity and electroconductive properties which allow it to mimic the native environment of cells within tissues. Some advantages of the hydrogel are its versatility (i.e., it mimics different kinds of tissues), its biocompatibility, mechanical properties, printability and electroconductivity. A superior biocompatibility is provided by the presence of some biomolecules capable of conferring a therapeutic potential to the hydrogel, for example, they may provide antimicrobial, immunomodulatory, antiaging, antioxidant, or anti-inflammatory effects, among others, which are key to assure that the regeneration process is accelerated. In terms of the mechanical properties, the hydrogel offers the possibility to adjust the Young's modulus according to that of the tissue to regenerate. Matching the mechanical properties of the tissue is of the utmost importance to assure proper cell proliferation and tissue remodeling. Printability facilitates forming constructs with sufficient shape fidelity after printing to ultimately maintain the integrity of the material during maturation and even post-implantation. Finally, electroconductivity is useful to circulate currents locally and to accelerate the rates of cell proliferation, cell differentiation, signal propagation and angiogenesis. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparing an extrudable photocrosslinkable hydrogel which involves: (a) biochemically modifying ECM pregel; and (b) treating the modified ECM pregel of step (a) with a working solution comprising a photoinitiator and an electroconductive nanomaterial.