• 专利标题:   Polymer-based foam material used in bone repair materials, comprises nano-hydroxyapatite, nanocellulose, polylactic acid, foaming agent, activating agent, antioxidant, heat stabilizer and biodegradation accelerator.
  • 专利号:   CN115068693-A
  • 发明人:   ZHANG Y, YANG K, ZHU Y, YANG J, CHEN Z, ZHAO Y, ZHANG X
  • 专利权人:   UNIV NORTHEAST FORESTRY
  • 国际专利分类:   A61L027/42, A61L027/56, A61L027/58
  • 专利详细信息:   CN115068693-A 20 Sep 2022 A61L-027/42 202302 Chinese
  • 申请详细信息:   CN115068693-A CN10266648 11 Mar 2021
  • 优先权号:   CN10266648

▎ 摘  要

NOVELTY - A polymer-based foam material comprises 20-80 pts. wt. nano-hydroxyapatite, 5-30 pts. wt. nanocellulose, 10-50 pts. wt. polylactic acid, 0.5-12 pts. wt. foaming agent, 0.05-0.50 pt. wt. activating agent, 0.1-0.5 pt. wt. antioxidant, 1-5 pts. wt. heat stabilizer and 10-50 pts. wt. biodegradation accelerator. USE - The polymer-based foam material is used in bone repair materials e.g. self-bone and metal prostheses, uses include but are not limited to bone tissue component, bone tissue substitute material, bone growth factor, pore connectivity, and nano cellulose/hydroxyapatite/polylactic acid composite material. ADVANTAGE - The biodegradable composite material has excellent biocompatibility, biological degradability, pore connectivity, and excellent mechanical performance. The material preparation process has no pollution, and is simple and easy to realize. The foaming composite material solves the problem that the mechanical strength of hydroxyapatite is low, the pores cannot communicate, and the degradation rate is low. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a preparation method of the polymer-based foam material comprising drying the nano-cellulose/hydroxyapatite nano-composite powder material, polylactic acid, polycarbonate, activating agent, antioxidant, heat stabilizer and biodegradation accelerator for 8 hours at 60℃, putting the nano-cellulose/hydroxyapatite nano-composite powder material, polylactic acid, polycarbonate, activating agent, antioxidant, heat stabilizer and biodegradation accelerator into a high-speed mixer for mechanical stirring and mixing for 10 minutes, extruding and granulating the mixture by a double-screw extruder to prepare foaming master batches, weighing the master batches, putting the master batches into a mold to be foamed, setting the temperature to be 165℃ for 5 hours to obtain the nano-cellulose/hydroxyapatite/polylactic acid foamed composite material.