• 专利标题:   Composite material useful e.g. as antimicrobial, in a formed article (e.g. filter medium) and to target a cell with an imaging or therapeutic agent, comprises a functionalized graphene material e.g. graphene oxide, and a protein or peptide.
  • 专利号:   US2013266628-A1
  • 发明人:   THALAPPIL P, SREENIVASAN S T, MALIYEKKAL S M
  • 专利权人:   INDIAN INST TECHNOLOGY MADRAS
  • 国际专利分类:   A01N025/08, A01N037/18, A01N059/00, A01P001/00, B82Y015/00, C12N005/09, C12Q001/02, G01N021/64
  • 专利详细信息:   US2013266628-A1 10 Oct 2013 A01N-059/00 201372 Pages: 6 English
  • 申请详细信息:   US2013266628-A1 US443408 10 Apr 2012
  • 优先权号:   US443408

▎ 摘  要

NOVELTY - Composite material comprises: at least one functionalized graphene material comprising graphene, graphene oxide and/or reduced graphene oxide; and at least one protein or peptide. USE - The composite material is useful: as antimicrobial; as a free-standing film, a coating on a substrate, an embedded constituent of a second composite material, a nanoparticle and/or a microparticle; in a formed article such as a food packaging material, a filter medium, or a targeted medical device; for targeting a cell with an imaging or therapeutic agent, where the cell overexpresses transferrin receptors, the cell is of a cell line comprising MDA-MB-435, MDA-MB-468, LXFL-592, L292, K562, HeLa, H-Meso, HL60, Hep2, KB-3-1, KB-8-5, KB-C1, KB-V1, MCF-7, scU87Mg, U251MG, K562 and/or MOLT4, and is a cancerous cell; and for treating an area containing or thought to contain microorganisms (all claimed). ADVANTAGE - The composite material: can be manufactured in a simple process; and shows much higher antimicrobial activity compared to individual reduced graphene oxide, chitosan, and native lactoferrin alone. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) a method (M1) for preparing the composite material, comprising: providing at least one functionalized graphene material comprising graphene oxide, reduced graphene oxide, sulfonated graphene, sulfonated graphene oxide and/or sulfonated reduced graphene oxide; providing at least one protein; and contacting the functionalized graphene material with the protein to produce the composite material; (2) a method (M2) for targeting a cell with an imaging or therapeutic agent, comprising: providing the composite material; and contacting the cell with the composite material, where the cell is targeted with an imaging or therapeutic agent; and (3) a method (M3) for treating an area containing or thought to contain microorganisms, comprising: providing the composite material; and contacting the area with the composite material, where microorganisms in the contacted area are exterminated or their growth is inhibited.