• 专利标题:   Homogeneous composition useful in liver cancer embolism/thermal radiation combined treatment agent or embolic agent, comprises functional nano-drug uniformly dispersed in iodized oil injection using supercritical carbon dioxide.
  • 专利号:   CN113171452-A, CN113171452-B
  • 发明人:   LIU G, CHU C, DAI Q, XU D, CHENG H
  • 专利权人:   UNIV XIAMEN
  • 国际专利分类:   A61J003/08, A61K041/00, A61K047/12, A61K047/18, A61N002/00, A61N005/06, A61P035/00, B82Y040/00, B82Y005/00
  • 专利详细信息:   CN113171452-A 27 Jul 2021 A61K-041/00 202167 Pages: 9 Chinese
  • 申请详细信息:   CN113171452-A CN10256221 09 Mar 2021
  • 优先权号:   CN10256221

▎ 摘  要

NOVELTY - Homogeneous composition comprises functional nano-drug uniformly dispersed in iodized oil injection using supercritical carbon dioxide. The concentration of functional nano-drug in iodized oil is 0.1-20 mg/ml. The functional nano-drug has magnetocaloric properties or photothermal properties, and the surface is modified with oleic acid or oleylamine. USE - The composition is useful in liver cancer embolism/thermal radiation combined treatment agent or embolic agent (claimed). ADVANTAGE - The composition is inserted into tumor area; and has good dispersibility, and long-term storage. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing the composition, comprising (i) adding iodized oil injection and functional nano-drug into high pressure reaction kettle; (ii) injecting carbon dioxide into reaction kettle, pressurizing at 10-20 Mpa to form supercritical environment, and continuously stirring for 1-2 hours; and (iii) vacuum extracting, and collecting nano-drug-iodized oil homogeneous embolic agent from the reaction kettle.