▎ 摘　　要

NOVELTY - Iontophoresis electrode based on collagen/nano carbon composite drug-loaded conductive coating comprises combining coating with a crosslinking agent on substrate. The main components of the coating are collagen, nano carbon materials and medical drugs. The structure utilizes the collagen network as the framework. The surface-activated nano-carbon is loaded with medical drugs and combined with collagen fibers and evenly dispersing in the collagen network. The mass ratio of collagen to nano-carbon is 1:1-15:1. USE - The iontophoresis electrode based on collagen/nano carbon composite drug-loaded conductive coating is useful in field of medical rehabilitation. ADVANTAGE - The coating has good conductivity and biocompatibility, and can self-provide partial antibacterial or antiinflammatory medicine auxiliary introducing ion treatment. The method is simple in process, is easy to realize, which is better for popularization and application. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing iontophoresis electrode based on collagen/nanocarbon composite drug-loaded conductive coating comprising mixing and dissolving collagen raw materials with 0.01-1 mol/l dilute hydrochloric acid or acetic acid, and preparing a collagen solution with a concentration of 0.1-5 mg/ml, (ii) dispersing nano-carbon into a slurry with mixed acid, heating at 20-200 degrees C for surface activation treatment, lasting for 2-24 hours, cooling, filtering to obtain activated nano carbon, drying at 20-50 degrees C for 1-12 hours, adding the collagen solution in (1) at a concentration of 0.1-5 mg/ml, and stirring thoroughly, (iii) adding the cross-linking agent into the mixed solution in (ii) at a concentration of 0.01-2 mol/l, and stirring for 0.5-5 hours to obtain the mixed solution, (iv) adding medical medicines to the mixture in (iii) at a concentration of 0.1-2 mg/ml, stirring for 0.5-2 hours; (v) at -20 to 0 degrees C, coating above-mentioned mixture using low-temperature casting method on the substrate with a thickness of 1-20 mu m, allowing to stand for no more than 2 hours, introducing it in the refrigerator at -80 to 0 degrees C for 6-24 hours, (vi) drying above sample at low temperature and reduced pressure at -80 to 0 degrees C and 5-100 kPa for 2-10 hours, taking out the sample, washing and drying at 20-40 degrees C for 1-12 hours, and obtaining iontophoresis electrode based on collagen/nanocarbon composite drug-loaded conductive coating