• 专利标题:   Method for synthesizing L-phenylalanine, involves adding L-aspartic acid to phosphorus trichloride to obtain L-aspartic acid anhydride hydrochloride and carrying out Friedel-Crafts reaction using sulfonated graphene as catalyst.
  • 专利号:   CN106748844-A, CN106748844-B
  • 发明人:   WANG S, FU D, MA S, TAN W, WANG J
  • 专利权人:   UNIV SICHUAN SCI ENGINEERING
  • 国际专利分类:   C07B053/00, C07C227/18, C07C229/36
  • 专利详细信息:   CN106748844-A 31 May 2017 C07C-227/18 201744 Pages: 7 Chinese
  • 申请详细信息:   CN106748844-A CN11091683 01 Dec 2016
  • 优先权号:   CN11091683

▎ 摘  要

NOVELTY - The method for synthesizing L-phenylalanine involves adding L-aspartic acid to phosphorus trichloride to obtain L-aspartic acid anhydride hydrochloride, carrying out Friedel-Crafts reaction using sulfonated graphene as catalyst, carrying out hydrogenation reaction using carbonyl groups under palladium on carbon to obtain L-phenylalanine hydrochloride, neutralizing alkaline water and hydrochloride, cooling, crystallizing, centrifuging and filtering to obtain L-phenylalanine product. USE - Method for synthesizing L-phenylalanine (claimed). ADVANTAGE - The method enables synthesizing of L-phenylalanine with product purity of greater than or equal to 99.5% and total yield of more than 90%. DETAILED DESCRIPTION - Method for synthesizing L-phenylalanine involves carrying out dehydration reaction, acylation reaction, reduction reaction and neutralization reaction. The specific process is carried out by adding L-aspartic acid to phosphorus trichloride to obtain L-aspartic acid anhydride hydrochloride, carrying out Friedel-Crafts reaction using sulfonated graphene as catalyst, carrying out hydrogenation reaction using carbonyl groups under palladium on carbon to obtain L-phenylalanine hydrochloride, neutralizing alkaline water and hydrochloride, cooling, crystallizing, centrifuging and filtering to obtain L-phenylalanine product.