• 专利标题:   Medical device used for detecting analytes, comprises self-assembled monolayer containing substituted porphyrin arranged on outer surface of graphene layer through electrostatic interaction between partial positive charge on hydrogen atoms of hydrocarbon of monolayer, pie-electron system of graphene.
  • 专利号:   US2022291198-A1
  • 发明人:   NELSON J T, KOESTER S J, BUHLMANN P P J, ZHEN X
  • 专利权人:   UNIV MINNESOTA, BOSTON SCI SCIMED INC
  • 国际专利分类:   G01N027/12, G01N027/22, G01N033/497
  • 专利详细信息:   US2022291198-A1 15 Sep 2022 G01N-033/497 202283 English
  • 申请详细信息:   US2022291198-A1 US707214 29 Mar 2022
  • 优先权号:   US662305P, US707214

▎ 摘  要

NOVELTY - Medical device comprises graphene layer; self-assembled monolayer arranged on outer surface of graphene layer through electrostatic interactions between partial positive charge on hydrogen atoms of one or more hydrocarbons of self-assembled monolayer and π-electron system of graphene; and self-assembled monolayer comprises one or more substituted porphyrins or substituted metalloporphyrins, or derivatives. USE - Medical device used for modifying surface of graphene to create medical device component and detecting analytes (all claimed), for detection of diseases. ADVANTAGE - The medical device enables to allow early detection of particular disease states, and provide better treatment outcomes. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a method for modifying surface of graphene to create medical device component, which involves: (a) forming self-assembled monolayer arranged on outer surface of graphene layer through electrostatic interactions between partial positive charge on hydrogen atoms of hydrocarbons of self-assembled monolayer and π-electron system of graphene, where self-assembled monolayer, which comprises substituted porphyrins or substituted metalloporphyrins, or derivatives; and (b) quantifying extent of surface coverage of self-assembled monolayer using contact angle goniometry, Raman spectroscopy, or X-Ray photoelectron spectroscopy; (2) a method for detecting analytes, which involves: (a) collecting gaseous sample from patient; (b) contacting gaseous sample with graphene component, each graphene component, which further comprises graphene layer; (b) arranging self-assembled monolayer on outer surface of graphene layer through electrostatic interactions between partial positive charge on hydrogen atoms of hydrocarbons of self-assembled monolayer and π-electron system of graphene.