• 专利标题:   Neural multifunctional device for electrical measurement and stimulation application to nerve cells and delivery of medicinal substances to nerve cells, has nanotubes which are arranged on two-dimensional nanomaterial layer region to perform electrical measurement and stimulation to nerve cells.
  • 专利号:   WO2023033277-A1, KR2023034084-A
  • 发明人:   YI G, LEE J, LEE J M
  • 专利权人:   UNIV SEOUL NAT R DB FOUND
  • 国际专利分类:   A61B005/00, A61B005/263, A61B005/294, A61M037/00, A61N001/05, A61N001/36
  • 专利详细信息:   WO2023033277-A1 09 Mar 2023 A61B-005/294 202323 Pages: 29
  • 申请详细信息:   WO2023033277-A1 WOKR003431 11 Mar 2022
  • 优先权号:   KR117242

▎ 摘  要

NOVELTY - The device (100) has a two-dimensional nanomaterial layer (10) in which holes (H10) are formed, and the openings (A10) having larger diameter than the hole, that are arranged on the nanomaterial layer. A mask layer (20) is formed to expose the nanotubes (30) vertically arranged on the two-dimensional nanomaterial layer region exposed around the holes by the mask layer and has passages (P10) for material movement. A binding layer (40) is arranged on the mask layer to fill up a region between and around the nanotubes to a given height. An electrode structure (50) is arranged on the binding layer to be electrically connected to the nanotubes. The nanotubes are arranged to perform electrical measurement and application of stimulation to nerve cells by the transfer of substance to a nerve cell. The nanomaterial layer includes graphene. The binding layer is made of polymer. The nanotubes are formed of metal oxide, zinc oxide. USE - Neural multifunctional device for electrical measurement and stimulation application to nerve cells and delivery of medicinal substances to nerve cells. ADVANTAGE - Since electrical measurement and/or stimulation of nerve cells and mass transmission can be performed together using one device, measurement can be easily performed and measurement accuracy can be improved. Since the response to a predetermined medicinal substance can be easily measured in an electrical manner while delivering substance to the nerve cell, research or experiments on the nerve cell can be facilitated, and evaluation of a predetermined drug is also facilitated. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a manufacturing method of neural multifunctional device. DESCRIPTION OF DRAWING(S) - The drawing shows a cross-sectional view of a neural multifunctional device. 10Two-dimensional nanomaterial layer 20Mask layer 30Nanotube 40Binding layer 50Electrode structure 100Neural multifunctional device A10Opening H10Hole P10Passage