▎ 摘　　要

NOVELTY - Graphene oxide comprises chemical structure comprising carbon-carbon double bond, carbon-carbon single bond or carbon-hydrogen bond, and the surface containing at least one or more functional groups chosen from hydroxyl, carbonyl, carboxyl and epoxy, and the interface potential is -20 to -50 mV. USE - The graphene oxide is useful in pharmaceutical composition for preparing medicament for prophylaxis or treatment of disease caused by angiogenesis or growth, treating cancer, inhibiting tumor cell proliferation and angiogenesis and as vascular endothelial growth factor tracer for tracing the tumor location in targets. The diseases caused by angiogenesis or growth are chosen from tumor, arthritis, abnormal ocular angiogenesis, thyroid hyperplasia, atherosclerosis, obesity and gastrointestinal ulcers. The target is vertebrate, preferably mammal. The mammal is human (all claimed). DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) pharmaceutical composition (C1) comprising the above-mentioned graphene oxide and carrier, diluent or excipient; (2) pharmaceutical composition (C2) comprising the composition of graphene oxide and vascular endothelial growth factor; and (3) method for adsorbing vascular endothelial growth factor within a target, involves administering an amount of monolithic oxide to target substance.