▎ 摘　　要

NOVELTY - Solid phase extraction material comprises solid phase substrate surface modified graphene oxide or reduced graphene oxide. The solid substrate is glass beads or magnetic beads. USE - The solid phase extraction material is useful in kit for performing enrichment and/or detection of nucleic acids (all claimed). ADVANTAGE - The solid phase extraction material rapidly adsorbs nucleic acids, preferably short single-stranded nucleic acids through electrostatic action force, hydrogen bonds and pi - pi acting force, reduces detection limit of nucleic acid sample and detects nucleic acid with improved sensitivity. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) method for preparing the solid phase extraction material, involves mixing dispersion liquid of graphene oxide or reduced graphene oxide with solid-phase substrate to obtain product; (2) kit comprises solid-phase extraction material; (3) method for enriching nucleic acid, involves mixing sample with solid-phase extraction material, separating the solid-phase extraction material, washing and eluting to obtain a nucleic acid solution; (4) kit comprises the solid phase extraction material, specific probe and in-situ amplification reagent; and (5) method for detecting nucleic acid, involves mixing sample with solid-phase extraction material, separating solid-phase extraction material, mixing with a specific probe and in-situ amplification reagent, amplifying, and detecting the amplification product by electrophoresis.