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  • 专利标题:   Magnetic composition for performing MRI of subject comprises magnetic metal, and graphene-like nanostructure or graphitic nano- or microstructure.
  • 专利号:   WO2012154677-A1, CA2835262-A1, EP2704902-A1, US2014161730-A1, JP2014516206-W, KR2014082595-A, CN103826840-A, CN103826840-B, JP6139511-B2, US9713650-B2, EP2704902-A4, US2017312374-A1
  • 发明人:   SITHARAMAN B, PARATALA B S, PARATALA B
  • 专利权人:   UNIV NEW YORK STATE RES FOUND, UNIV NEW YORK STATE RES FOUND, UNIV NEW YORK STATE RES FOUND, UNIV NEW YORK STATE RES FOUND, SITHARAMAN B, PARATALA B S
  • 国际专利分类:   B32B009/00, A61K049/10, C01B031/02, C01B031/04, H01F001/00, H01F001/08, H01F001/11, A61K049/00, C01B032/15, C01B032/152, C01B032/158, C01B032/18, C01B032/182, A61B005/055, B82Y015/00, B82Y030/00, B82Y040/00, B82Y005/00
  • 专利详细信息:   WO2012154677-A1 15 Nov 2012 B32B-009/00 201277 Pages: 113 English
  • 申请详细信息:   WO2012154677-A1 WOUS036790 07 May 2012
  • 优先权号:   US483309P, CA2835262, KR731518, US14116102, US644172

▎ 摘　　要

NOVELTY - A magnetic composition (C1) comprises: a magnetic metal; and a graphene-like nanostructure or a graphitic nano- or microstructure. USE - For MRI of subject (preferably mammal, especially human) (claimed). ADVANTAGE - The magnetic composition has a relaxivity r1 of ( greater than or equal to 10, preferably greater than or equal to 20, especially greater than or equal to 45) mM-1second-1, where relaxivity is important measure of efficacy of MRI contrast agent. The relaxivity values at 0.47T for oxidized micro-graphite, oxidized graphene nanoplatelets, reduced graphene nanoplatelets and graphene nanoribbons were tested at 40 degrees C, and compared to clinically approved Gd3+-based and Mn2+ based chelate complexes; where micro-graphite, oxidized graphene nanoplatelets, reduced graphene nanoplatelets and graphene nanoribbons show significantly higher r1 and r2 relaxivities compared to paramagnetic chelate complexes. At 0.47T, the r1 and r2 values for graphite and graphene samples are 8-10 times, and 19-60 times greater than paramagnetic chelate complexes. Among graphitic and graphene samples at 0.47T, graphene nanoribbons, and oxidized graphite showed higher (20%) r1 values than oxidized graphene nanoplatelets and reduced graphene nanoplatelets. The nuclear magnetic resonance dispersion (NMRD) profiles between 0.01-80 MHz of aqueous solutions of oxidized graphite, oxidized graphene nanoplatelets, reduced graphene nanoplatelets and graphene nanoribbons, showed longitudinal r1 relaxivities for these compounds over large magnetic field range (0.01-80). DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a composition (C2) for use with MRI, comprising: the magnetic composition (C1), and at least one carrier or excipient; (2) method (M1) for performing MRI of a subject, involving: administering to the subject the magnetic composition (C1); and imaging the subject by using MRI device; and (3) method (M2) for producing the magnetic composition comprising magnetic metal and graphene-like carbon nanostructure, involving: (a) treating graphite with a mixture of sulfuric acid (H2SO4), sodium nitrate (NaNO3), (MnCl2), and potassium permanganate (KMnO4), and (b) sonicating a suspension of the product obtained in step (a); or (a1) treating a multi-walled carbon nanotube with sulfuric acid, MnCl2, and KMnO4.