• 专利标题:   Wearable sweat sensor system for monitoring key metabolites, comprises sweat sensor patch applied to human skin, microfluidic sweat sampling and collection module for collecting induced sweat sample, and metabolite detection module for identifying concentration of metabolites present in sample.
  • 专利号:   US2023157592-A1, WO2023097037-A1
  • 发明人:   YANG Y, GAO W
  • 专利权人:   CALIFORNIA INST OF TECHNOLOGY, CALIFORNIA INST OF TECHNOLOGY
  • 国际专利分类:   A61B010/00, A61B005/00, A61B005/01, A61B005/145, A61B005/1477, A61B005/16, A61N001/32, G06N020/00, G16H010/20, G16H050/30, G16H050/80
  • 专利详细信息:   US2023157592-A1 25 May 2023 A61B-005/145 202346 English
  • 申请详细信息:   US2023157592-A1 US993602 23 Nov 2022
  • 优先权号:   US283021P, US993602

▎ 摘  要

NOVELTY - A wearable sweat sensor system comprises a wearable sweat sensor patch applied to a human subject's skin, a multi-inlet microfluidic sweat sampling and collection module for collecting an induced sweat sample for analysis, a metabolite detection module for identifying concentrations of target metabolites present in the collected sweat sample, and a smart device for analyzing the detected metabolite concentration and displaying information based on the analyzed metabolite concentration. USE - Wearable sweat sensor system for monitoring key metabolites. ADVANTAGE - The wearable sweat sensor system is lightweight, cost-effective, comfortable, non-invasive, and easily worn by a human patient as needed for extended period of time, and measures key biomarkers comparably to blood testing. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: 1. Sweat sensor patch (100), which comprises an iontophoresis module for administering sweat induction agent that stimulates production of sweat, a multi-inlet sweat sampling and collection module for collecting an induced sweat sample, a molecularly imprinted polymer (MIP) organic compound sensor module for analyzing the induced sweat sample, and a metabolite detection module for identifying concentrations of target metabolites present in the collected sweat sample; 2. Wearable biofluid sampling system; 3. A sweat induction and collection method, which involves: (i) applying a stimulating agent to a human sweat gland, where the stimulating agent stimulates production of sweat sample; (ii) collecting the stimulated sweat in a multi-inlet microfluidic module; (iii) emptying the collected sweat sample from the reservoir; (iv) collecting a fresh sweat sample in the multi-inlet microfluidic module; and (v) repeating steps three and four over a period of time to collect refreshed sweat samples; and 4. MIP detection method, which involves: (a) polymerizing functional monomers with template molecules; (b) forming a complex with target molecule using the functional monomer and a crosslinker; (c) embedding a functional group of the functional monomer and crosslinker in a polymeric structure laser engraved graphene (LEG); (d) extracting the target molecule; and (e) revealing binding sites on an LEG-MIP electrode that are complementary in size, shape, and charge to the target molecule. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of wearable sweat sensor. 100Sweat sensor patch 102Backing layer 104Biosensor array 106Electrodes 108Biosensor