• 专利标题:   Injectable photothermal chemotherapy sensitizing drug-loaded hydrogel comprises injectable hydrogel and drug-loaded nanomicelles.
  • 专利号:   CN112972366-A
  • 发明人:   ZHANG C, HUANG S
  • 专利权人:   ZHANG C, HUANG S
  • 国际专利分类:   A61K031/12, A61K031/704, A61K041/00, A61K047/24, A61K047/26, A61K047/34, A61K009/06, A61K009/107, A61K009/127, A61K009/51, A61P035/00, B82Y030/00, B82Y040/00, B82Y005/00
  • 专利详细信息:   CN112972366-A 18 Jun 2021 A61K-009/06 202163 Pages: 12 Chinese
  • 申请详细信息:   CN112972366-A CN10134054 29 Jan 2021
  • 优先权号:   CN10134054

▎ 摘  要

NOVELTY - An injectable photothermal chemotherapy sensitizing drug-loaded hydrogel comprises injectable hydrogel and drug-loaded nanomicelles. The injectable hydrogel is synthetic phospholipid with temperature-sensitive properties. The drug-loaded nanomicelles include nanoparticles with photothermal conversion effect. USE - The drug-loaded hydrogel is used for injectable photothermal chemotherapy sensitizing. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of the drug-loaded nanomicelles comprising dissolving liposomes and hydrophobic chemotherapeutic drugs in organic solvents, and removing organic solvents to form drug-loaded liposome films; and forming hydrophilic chemotherapeutics, nanoparticles with photothermal conversion effect and water into mixed solution, adding mixed solution dropwise to drug-loaded liposome film for ultrasound, and subjecting to dialysis treatment.