▎ 摘　　要

NOVELTY - Methimazole adsorbant sample slide comprises a glass substrate, and adsorbant coating on a surface of the glass substrate, where the adsorbant coating comprises graphene-dendrimer-stabilized silver nanoparticles (G-D-Ag), where the G-D-Ag of the adsorbant coating comprises a graphene oxide sheet chemically bonded with at least 2 polyamidoamine (PAMAM) dendrimers through carboxamide bonds (I), and silver nanoparticles bound to the graphene oxide sheet supported PAMAM dendrimer, where weight ratio of silver nanoparticles relative to the graphene oxide sheet is 1:1-3:1. USE - The slide is useful for: detecting methimazole or determining concentration of methimazole in a sample e.g. drug or chemical sample, serum, plasma, urine, human serum, plasma, urine, sample obtained from domestic cat or other member of the family Felidae, or the sample is from a subject having hyperthyroidism or at risk, female who is pregnant or who may become pregnant, subject having, genetically predisposed to having, or at risk of having agranulocytosis, aplastic anemia (pancytopenia), ANCA-positive vasculitis, exfoliative dermatitis, hepatitis, or hepatic dysfunction or at least one symptom, or subject having anorexia, pruritus, or right upper quadrant pain or other symptom of hepatic dysfunction and abnormal liver function test. ADVANTAGE - The slide provides improved sensitivity, and is easy to use. DETAILED DESCRIPTION - Methimazole adsorbant sample slide comprises a glass substrate, and adsorbant coating on a surface of the glass substrate, where the adsorbant coating comprises graphene-dendrimer-stabilized silver nanoparticles (G-D-Ag), where the G-D-Ag of the adsorbant coating comprises a graphene oxide sheet chemically bonded with at least 2 polyamidoamine (PAMAM) dendrimers through carboxamide bonds of formula (I), where X = -A-B-NH2, A-B-N-(A-B-NH2)2, or -A-B-N-A-B-N-(A-B-NH2)22, A = CH2CH2C(O), B = NHCH2CH2, graphene = graphene oxide sheet, and m 2-100, and silver nanoparticles bound to the graphene oxide sheet supported PAMAM dendrimer, where weight ratio of silver nanoparticles relative to the graphene oxide sheet is 1:1-3:1. An INDEPENDENT CLAIM is also included for detecting methimazole or determining concentration of methimazole in a sample comprising contacting the sample containing or suspected of containing MTZ with the methimazole adsorbant sample slide, adsorbing the MTZ to the G-D-Ag of the adsorbant coating, and performing surface-enhanced raman scattering (SERS) of the G-D-Ag adsorbed MTZ.