▎ 摘　　要

NOVELTY - Magnetic stimulating material, obtained by co-precipitation of functionalized graphene with good hydrophilicity and biocompatibility and magnetic nanoparticles with a mass ratio of 1:2-1:20, is claimed. USE - The magnetic stimulating material is useful for promoting directed transdifferentiation of Muller cells in eye in preparing material for promoting retinal ganglion cell (RGC) repair i.e. glaucoma, optic nerve atrophy and optic neuritis (all claimed). ADVANTAGE - The magnetic stimulating material: stimulates long-range alternating magnetic field; activates Muller cell damage repair and regeneration-related signal pathways; realizes the directed transdifferentiation regulation of Muller cells into optic ganglion cells; and provides new ideas and ways for clinical treatment of optic nerve injury diseases. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: preparing the magnetic stimulation material, comprising (I) mixing graphite powder and water-soluble biopolymer in proportion, and ball-milling to obtain functionalized graphene with good hydrophilicity and biocompatibility, and (II) using the co-precipitation method, precipitating the magnetic nano-particle iron oxide on the functionalized graphene to obtain the nano-magnetic stimulation material; and repairing retinal ganglion cells (RGC) in optic nerve injury diseases, comprising dedifferentiating retinal Muller cells into neurospheres with stem cell potential, introducing the synthesized magnetic stimulation material with good superparamagnetism into the Muller cell neurosphere as an artificial magnetic receptor, under the high-target magnetic field signal reception and stimulation induction of the artificial magnetic receptor, activating the relevant signal pathways of Muller cells, regulating the directed transdifferentiation of Muller cells into RGC, where the intensity of the magnetic field is 5-20 mT, and the magnetic stimulation conditions are 1 hour per day, and continuously acting for 1-3 days.