▎ 摘　　要

NOVELTY - Drug delivery system comprises a drug delivery carrier, which encapsulates nucleic acid drugs and photothermal nanoparticles. USE - Used as drug delivery system. ADVANTAGE - The drug delivery system has created an unprecedented way of intracellular drug delivery, uses biocompatible, environmentally friendly, pollution-free, and pollution-free material, ha simple and convenient operation is simpler and more convenient, has low production cost, and has economical and environmentally friendly. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparation method a drug delivery system, comprising a microneedle patch coated with nucleic acid drugs and photothermal nanoparticles, (S1) preparing needle tip working solution as follows: (S11) dissolving raw materials for preparing the microneedles to form a mixed solution 1, (S12) adding photothermal nanoparticle solution and nucleic acid drug solution into the mixed solution 1, and mixing evenly to obtain needle tip working solution, (S2) preparing backing working solution, and (S3) adding needle tip working solution and backing working solution to the mold in sequence, drying and curing to obtain the microneedle patch.