• 专利标题:   Nucleic acid detection chip for nucleic acid amplification and detection, comprises electronic sensors, where surface of electronic sensor is modified with oligonucleotide upstream primers and/or downstream primers and primers are used for nucleic acid isothermal amplification reaction on chip.
  • 专利号:   CN114606297-A
  • 发明人:   WEI F, GOU L, WANG L, ZHANG Z
  • 专利权人:   CHENGDU ONECHIP BIOTECHNOLOGY CO LTD
  • 国际专利分类:   C12Q001/6844
  • 专利详细信息:   CN114606297-A 10 Jun 2022 C12Q-001/6844 202273 Chinese
  • 申请详细信息:   CN114606297-A CN11448949 09 Dec 2020
  • 优先权号:   CN11448949

▎ 摘  要

NOVELTY - Nucleic acid detection chip comprises one or more electronic sensors. The surface of the electronic sensor is modified with one or more oligonucleotide upstream primers and/or downstream primers. The primers are used for nucleic acid isothermal amplification reaction and detection on the chip. USE - Nucleic acid detection chip for nucleic acid amplification and detection (claimed). ADVANTAGE - The nucleic acid detection chip has reduced background interference, which improves the accuracy of nucleic acid detection and realizes simple and rapid multiple nucleic acid isothermal amplification reaction and detection on the chip. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a nucleic acid amplification and detection method, which involves adding a nucleic acid isothermal amplification reaction system to the nucleic acid detection chip, performing nucleic acid isothermal amplification reaction, and detecting electrical signal changes of the chip in the nucleic acid isothermal amplification reaction.