• 专利标题:   Amino-silicon phthalocyanine-graphene oxide composite nano material useful in preparing anticancer medicine for synergistic photodynamic and photothermal therapies.
  • 专利号:   CN107746411-A
  • 发明人:   LIU W, PAN J, LI X, YANG Y, LIU J, LE K
  • 专利权人:   UNIV SHANDONG
  • 国际专利分类:   A61K041/00, A61P035/00, C07F007/10
  • 专利详细信息:   CN107746411-A 02 Mar 2018 C07F-007/10 201830 Pages: 12 Chinese
  • 申请详细信息:   CN107746411-A CN10967250 17 Oct 2017
  • 优先权号:   CN10967250

▎ 摘  要

NOVELTY - Amino-silicon phthalocyanine-graphene oxide composite nano material is claimed. The composite nano material is formed by bonding silicon phthalocyanine amine (I) with graphene oxide through covalent bond, where mass ratio of amino-silicon phthalocyanine to graphene oxide is 0.1-8:1-9. USE - The nano material is useful in preparing anticancer medicine for synergistic photodynamic and photothermal therapies (claimed). ADVANTAGE - The nano material: exhibits excellent synergistic effects of photodynamic therapy and thermal treating in vitro cell experiment and living mice experiment; improves fatality rate and treating efficiency of cancer cells; and has simple preparation method. DETAILED DESCRIPTION - Amino-silicon phthalocyanine-graphene oxide composite nano material is claimed. The composite nano material is formed by bonding silicon phthalocyanine amine of formula (I) with graphene oxide through covalent bond, where mass ratio of amino-silicon phthalocyanine to graphene oxide is 0.1-8:1-9. n = 0-10. An INDEPENDENT CLAIM is also included for preparing amino-silicon phthalocyanine-graphene oxide composite nano material comprising (i) oxidizing graphene in N,N-dimethylformamide, and ultrasonically dispersing to obtain suspension, (ii) adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride into suspension, then adding N-hydroxylsuccinimide, N,N-diisopropylethylamine and (I), reacting at normal temperature by stirring under nitrogen atmosphere, and (iii) separating and purifying the reaction product, and then freeze-drying the obtained solid product to obtain final product.