▎ 摘　　要

NOVELTY - Additive comprises a complex in which at least one metal nanoparticle is bonded to at least one surface of graphene oxide. USE - The additive is useful for reducing noise in loop-mediated isothermal amplification reaction. The loop-mediated isothermal amplification reaction is a reverse transcription loop-mediated isothermal amplification reaction (all claimed). ADVANTAGE - The additive improves accuracy of detection of a target on amplification reaction. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a loop-mediated isothermal amplification reaction composition, which comprises the additive.