▎ 摘　　要

NOVELTY - Implantable cell containing device comprises a scaffold and a cell-containing hydrogel encapsulating the scaffold, where the scaffold comprises a tracheal-like internal system of continuous air-filled, hydrophobic micro-channels that traverse the scaffold's dimensions, and a hydrophilic external surface. USE - The implantable cell containing device is useful for treating diabetes, bleeding disorder, lysosomal storage disease, neurological disorder, cancer, chronic eye disease, kidney failure, or chronic pain, where the bleeding disorder comprises hemophilia A, hemophilia B, von Willebrand disease, Factor I deficiency, Factor II deficiency, Factor V deficiency, Factor VII deficiency, Factor X deficiency, Factor XI deficiency, Factor XII deficiency, or Factor XIII deficiency, the neurological disorder comprises Parkinson's disorder, Alzheimer's disease, epilepsy, Huntington's disease, Amyotrophic lateral sclerosis, chronic pain, visual loss, hearing loss, peripheral nerve injury, or spinal cord injury, the chronic eye disease comprises age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, glaucoma, or macular telangiectasia, and chronic pain is chronic pain caused by degenerative back and knee, neuropathic back and knee, or cancer (all claimed). No biological data given. ADVANTAGE - None given. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: delivering (M1) a therapeutic agent to a subject, comprising implanting the implantable cell containing device into the subject; treating (M2) diabetes, bleeding disorder, lysosomal storage disease, neurological disorder, cancer, chronic eye disease, kidney failure, or chronic pain in a subject, comprising implanting the implantable cell containing device into the subject; preparing (M3) a scaffold for a cell encapsulation system, comprising providing a mold, introducing a polymer solution into the mold and allowing the polymer to solidify and form a three-dimensional structure comprising a network of hydrophobic microchannels throughout the three-dimensional structure, and removing the mold to release the three-dimensional structure, thus forming the scaffold; caffold for use in a cell encapsulation system, the scaffold comprising a three-dimensional structure comprising a network of hydrophobic microchannels throughout the three-dimensional structure, and a hydrophilic external surface of the three-dimensional structure; and forming (M4) a cell encapsulation system suitable for implant, comprising providing a hydrogel precursor solution comprising at least one cell suspended in the hydrogel precursor solution, and combining the hydrogel precursor solution with a scaffold in a contained state, and allowing the hydrogel precursors to crosslink to form the hydrogel with the scaffold and at least one cell embedded within the hydrogel.