▎ 摘　　要

NOVELTY - Composition for detection of a target nucleic acid, comprises single-stranded probes comprising a sequence complementary to a target nucleic acid and a sequence complementary to another single-stranded probe and forming a three-dimensional nucleic acid nanostructure upon binding to a target nucleic acid; or comprises a first single-stranded probe, a second single-stranded probe, and a third single-stranded probe. The three-dimensional nucleic acid nanostructure contains a fluorescent material. The fluorescent material is not quenched even when reacted with graphene oxide. The single-stranded probe comprises a fluorescent material, and when the first single-stranded probe, the second single-stranded probe, and the third single-stranded probe bind to the target nucleic acid, a tetrahedral nucleic acid nanostructure is formed. USE - The composition is useful for detecting a target nucleic acid; and for providing information for diagnosing a disease or predicting the effect of a treatment method (all claimed). ADVANTAGE - The composition or kit for detecting a target nucleic acid with high specificity, sensitivity, and accuracy without the conventional high-cost and low-sensitivity PCR analysis process, and with low cost and less time in vitro. It is easy to use for science and medical fields such as diagnosis of most diseases involving biomarkers and prediction of the effects of therapeutic agents or treatment methods. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a kit or diagnostic kit for detecting a target nucleic acid comprising the composition and graphene oxide; (2) detecting a target nucleic acid which involves mixing and heat-treating the composition with the nucleic acid isolated from the sample; reacting with graphene oxide; and detecting fluorescence; and (3) providing information for diagnosing a disease or predicting the effect of a treatment method which involves mixing and heat-treating the composition with the nucleic acid isolated from the subject; reacting with graphene oxide; and detecting fluorescence.