• 专利标题:   Making graphene-oxide nanoribbons and silver coated gold nanoparticles used for electrochemical sensors to detect cancer by e.g. performing hybridization of dsDNA over probe modified working electrode by dipping electrode in target solution.
  • 专利号:   IN201911000276-A
  • 发明人:   CHAUHAN N, PAREEK S, JAIN U
  • 专利权人:   UNIV AMITY
  • 国际专利分类:   B82Y040/00, C12Q001/6886, G01N027/30, G01N027/327, G06T007/10
  • 专利详细信息:   IN201911000276-A 03 Sep 2021 B82Y-040/00 202182 Pages: 13 English
  • 申请详细信息:   IN201911000276-A IN11000276 03 Jan 2019
  • 优先权号:   IN11000276

▎ 摘  要

NOVELTY - Synthesizing graphene-oxide nanoribbons (GONRs) and silver coated gold nanoparticles for electrochemical sensors comprises: (a) synthesizing GONR using multi-wall carbon nanotube and potassium permanganate; (b) preparing gold nanoparticles (AuNPs) using chloroauric acid and trisodium citrate; after that synthesizing silver coated AuNPs using AuNPs and silver nitrate; (c) carrying put electrode position of GONR at gold coated of silver nanoparticles (AgNP) onto working electrode by cyclic voltammetry technique; (d) immobilizing ssDNA (probe) onto the modified working electrode (GONR at gold coated AgNPs); (e) performing hybridization of dsDNA (target) over the probe modified working electrode by dipping the electrode in the target sequence solution after immobilization; and (f) using various techniques e.g. cyclic voltammetry and square wave voltammetry for the electrochemical characterization. USE - The method is useful for synthesizing graphene-oxide nanoribbons and silver coated gold nanoparticles for electrochemical sensors (claimed) which is used for detecting cervical cancer e.g. pancreatic adenocarcinoma, ovarian carcinoma, mesothelioma, lung adenocarcinoma, squamous cell carcinoma, squamous cell cancer, small-cell lung cancer, non-small cell lung cancer, adenocarcinoma of the lung, squamous carcinoma of the lung, cancer of the peritoneum, hepatocellular cancer, gastrointestinal cancer, glioblastoma, cervical cancer, liver cancer, bladder cancer, hepatoma, breast cancer, colon cancer, colorectal cancer, endometrial or uterine carcinoma, salivary gland carcinoma, kidney cancer, liver cancer, prostate cancer, vulvar cancer, thyroid cancer, lymphoma, blastoma, sarcoma, and leukemia hepatic carcinoma and various types of head and neck cancers. No biological data given. ADVANTAGE - The method exhibits improved performance of electrochemical sensors due to their unique array of structural and chemical properties.