• 专利标题:   Magnetic-fluorescent bifunctional graphene oxide nanocomposite used as targeted drug carrier, contains graphene oxide, magnetic nanoparticles comprising ferroferric oxide nanoparticles, and fluorescent nanoparticles.
  • 专利号:   CN104263358-A, CN104263358-B
  • 发明人:   CHEN H, DENG Y, HUANG L, LIU H, ZHANG Y, XIA W, YU H, SUN L
  • 专利权人:   UNIV CHONGQING ARTS SCI
  • 国际专利分类:   C09K011/54
  • 专利详细信息:   CN104263358-A 07 Jan 2015 C09K-011/54 201520 Pages: 10 Chinese
  • 申请详细信息:   CN104263358-A CN10502642 26 Sep 2014
  • 优先权号:   CN10502642

▎ 摘  要

NOVELTY - A magnetic-fluorescent bifunctional graphene oxide nanocomposite contains three portions containing graphene oxide, magnetic nanoparticles and fluorescent nanoparticles. The magnetic nanoparticles comprise ferroferric oxide nanoparticles with mesoporous structure. The fluorescent nanoparticles contain zinc-oxide fluorescent nanoparticles having low toxicity and adjustable fluorescent color. The magnetic nanoparticles comprise material with magnetism and fluorescence functions. USE - Magnetic-fluorescent bifunctional graphene oxide nanocomposite is used as targeted drug carrier. ADVANTAGE - The magnetic-fluorescent bifunctional graphene oxide nanocomposite has high specific surface area and excellent biocompatibility, magnetic property and fluorescent characteristics. The targeted drug carrier formed using the magnetic-fluorescent bifunctional graphene oxide nanocomposite has tracing in the transmission path. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of magnetic-fluorescent bifunctional graphene oxide nanocomposite, which involves preparing graphene-oxide dispersion liquid by Hummer method using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide, preparing mesoporous iron oxide magnetic nanoparticles by sol-gel method, dissolving ferric nitrate in ethylene glycol, heating and stirring for predetermined time to form xerogel, placing xerogel in tube furnace at certain temperature and subjecting to pyrolysis, dissolving zinc acetate and lithium hydroxide in triethylene glycol, stirring to obtain magnesium acetate and purifying to obtain zinc oxide quantum dots with different emission colors, mixing zinc oxide quantum dots and mesoporous iron oxide magnetic nanoparticles by microemulsion method, coating resulting mixture on silica composite particles to form core-shell structure, and aminating mixture by covalent crosslinking method.