• 专利标题:   New functionalized graphene structure comprising graphene surface, 1-pyrenebutanoic acid succinimidyl ester molecules, polycyclic aromatic hydrocarbon compounds and biomolecules, used in electronic device for biological sample analysis.
  • 专利号:   EP4071466-A1, WO2022214698-A1
  • 发明人:   REBOLLO PINEIRO A, ARRASTUA CEBERIO M
  • 专利权人:   ATTENBIO SL, ATTENBIO SL
  • 国际专利分类:   B82Y015/00, G01N027/414
  • 专利详细信息:   EP4071466-A1 12 Oct 2022 G01N-027/414 202288 Pages: 18 English
  • 申请详细信息:   EP4071466-A1 EP382300 08 Apr 2021
  • 优先权号:   EP382300

▎ 摘  要

NOVELTY - Functionalized graphene structure (I) comprising: a graphene surface; 1-pyrenebutanoic acid succinimidyl ester (PBASE) molecules; molecules of at least one type of polycyclic aromatic hydrocarbon (PAH) compounds; and biomolecules, is new. Both the molecules of PBASE and molecules of PAH compounds are non-covalently linked to the graphene surface, where the biomolecule is linked to PBASE molecules. The PAH compound has at least four aromatic rings. The molecules of at least one type of PAH compound comprising pyrene, anthracene, chrysene, corannulene, naphthalene, phenanthrene, triphenylene, benzopyrene, coronene, tetracene, pentacene, and/or ovalene. The biomolecules are antibodies. USE - The functionalized graphene structure is useful as component in FET biosensor, which is used in an electronic device for biological sample analysis (all claimed). ADVANTAGE - The functionalized graphene structure improves chemical functionalization of graphene surface, and allows a more controlled and efficient way of preparing chemically modified graphene surfaces. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: preparing the functionalized graphene structure; a field-effect transistor (FET) biosensor comprising functionalized graphene structure; an electronic device for biological sample analysis comprising the FET biosensor; and electronic biological sample analysis using the electronic device. DESCRIPTION OF DRAWING(S) - The figure illustrates schematic view of non-covalent mixed functionalization of graphene surface and follow biofunctionalization with biomolecules (antibodies in this case) on a graphene transistor.