▎ 摘 要
NOVELTY - Preparing medicine packaging sheet with anti-pollution and antibacterial function comprises (1) slowly adding 200-250 ml concentrated sulfuric acid to a 1 l three-necked flask in an ice-water bath, adding 10-15 g graphite and 3-5 g sodium nitrate in turn, where the addition process must be slow, grinding graphite and sodium nitrate before adding, stirring for 1-1.5 hours, slowly adding 25-35 g potassium permanganate, mechanically stirring in an ice-water bath for 1.5-2 hours, heating, reacting for 2-2.5 hours, slowly adding 200-250 ml deionized water, heating the reaction system, stirring, adding 400-500 ml deionized water to the system, stirring for 2 minutes, adding 20-25 ml hydrogen peroxide to terminate the reaction, performing centrifugation, repeatedly washing with dilute hydrochloric acid and deionized water, and (2) using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) as cross-linking agents synthesis. USE - The method is useful for preparing medicine packaging sheet with anti-pollution and antibacterial function, which is used in medical market field for continuous improvement of medical packaging requirement. ADVANTAGE - The method: does not require special equipment and is easy to implement in industrialization. The product has low product cost and good compatibility between materials. DETAILED DESCRIPTION - Preparing medicine packaging sheet with anti-pollution and antibacterial function comprises (1) slowly adding 200-250 ml concentrated sulfuric acid to a 1 l three-necked flask in an ice-water bath, and then adding 10-15 g graphite and 3-5 g sodium nitrate in turn, where the addition process must be slow, repeatedly grinding graphite and sodium nitrate before adding, stirring for 1-1.5 hours, slowly adding 25-35 g potassium permanganate, mechanically stirring in an ice-water bath for 1.5-2 hours, heating to 30-40°C, and reacting for 2-2.5 hours, slowly adding 200-250 ml deionized water at 30-40℃, then heating the reaction system to 80-90℃ and stirring for 10-20 minutes, slowly adding 400-500 ml deionized water to the system, stirring for 2 minutes, adding 20-25 ml hydrogen peroxide to terminate the reaction, continuously stirring the reactant for 10-20 minutes, performing centrifugation, repeatedly washing with dilute hydrochloric acid and deionized water for multiple times until the pH of the product is 7 to obtain the graphene oxide (GO), (2) using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) as cross-linking agents synthesis, sonicating GO for 2-3 hours to disperse it in dimethylformamide, transferring the suspension after sonication to a three-necked flask, and the temperature of the reactor not to exceed 5°C, during the stirring process, adding 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide (EDC and NHS), carrying out the reaction at a speed of 200-300 revolutions/minute for 4-5 hours, drop wisely adding the diethylenetriamine (DETA) to the three-necked flask, rapidly stirring at room temperature for 6 hours at a rotational speed of 500-600 revolutions/minute to obtain a mixture of amino-functionalized graphene oxide (NGO), washing the mixed solution of NGO three times with deionized water to remove impurities, placing the product in a petri dish for freeze-drying with a vacuum dryer, sealing the obtained product and storing, (3) adding NGO in deionized water for 1 hour to ultrasonically disperse it uniformly, dispersing TiO2 in toluene solution by the same treatment method, mixing the suspension of NGO and the toluene solution after dispersing titanium oxide together according to the mass ratio of NGO and titanium oxide 5-10:95-90, and stirring for 4-5 hour and preparing amino-functionalized graphene oxide- titanium oxide (NGO-titanium oxide) composite catalyst, (4) adding NGO-titanium oxide to the composition system of PVC medicine packaging sheet according to the mass ratio of polyvinyl chloride to NGO-TiO2 of 100:0.02-1, and carrying out the production according to the existing traditional PVC medicine packaging sheet calendering process, (5) laminating the low density polyethylene (LDPE) film with a thickness of 10-30 microns and the antifouling and antibacterial function PVC sheet through a traditional calendering process to obtain the product. An INDEPENDENT CLAIM is also included for a medical drug packaging sheet.