▎ 摘　　要

NOVELTY - Clobetasol propionate molecule trap comprises using graphene oxide modified by polyethylene filter plate as the interior support; and the surface is compounded with clobetasol propionate trace molecular printing polymer film. USE - The molecular trap is useful in selectively separating, enriching and purifying the sample of clobetasol propionate residue (claimed). ADVANTAGE - The method is simple, low cost, and has less use of organic solvents, solid phase extraction of simple and rapid operation, and has high efficiency.The composition has synergistic effect DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for (1) preparing clobetasol propionate molecule trap comprising using surface printed trace polymerization method, phase extraction the polyethylene micro-pore filter plate of small column using commodity solid as carrier and silanized graphene oxide modified polyethylene filter plate, then taking the polyethylene filter plate after being modified as interior support, clobetasol propionate as template molecule, 3-amino propyl triethyl silane as functional monomer, tetraethoxysilane as crosslinking agent, glacial acetic acid as silane hydrolysis condensation, according to mol ratio of 8-24 piece, 1-3 mmol: 20-60 mmol: 45-135 mmol: 2-6 ml, carrying out the polymerization reaction, then eluting to remove the template molecule clobetasol propionate to obtain; and (2) using method of clobetasol propionate molecule trap (i) activating the clobetasol propionate molecule trap 4 sheet is arranged in the wide-mouth bottle, activated by 3 ml methanol, removing waste liquid, eluting with 3 ml acetonitrile, the surface of the molecular trap methanol removal, removing waste liquid, then using 3 ml acetonitrile, removing waste liquid, obtaining activated clobetasol propionate molecule trap, (ii) extracting precisely weighing the cosmetic sample 0.2 g, adding into centrifugal tube, accurately adding 1 ml acetonitrile, 10 ml saturated sodium chloride solution, ultrasonically extracting for 5 minutes, centrifuging at rotating speed of 10000 rotations/minute (rpm) for 10 minutes, accurately pick-up displacing the upper acetonitrile extracting solution 5 ml wide-mouth bottle, adding and mixed with the activated molecular trap obtained in the step (i), under the action of vibration extracting for 2 hours, after finishing extracting, taking a molecular trap, removing waste liquid, (iii) leaching with 3 ml acetonitrile washing the resulting processed molecular trap. removing waste liquid, (iv) eluting with 3-15 ml methanol as eluant, the molecular trap to elute, collecting the eluent, collecting the obtained eluent to dry, to obtain the residue by nitrogen at 35 degrees C, dissolving the residue again with 1 ml acetonitrile, carrying out high-efficient liquid phase chromatographic analysis and filtering with 0.45 mu m filter.