• 专利标题:   Long-acting antibacterial-type absorbable orthopedic device material comprises macro-molecule polymer, reinforced-toughening graphene with dispersively distributed polymer, and biodegradable carrier material loaded with silver ion component.
  • 专利号:   CN103768663-A, CN103768663-B
  • 发明人:   BAI J, CHU C, GUO C, LIN P, LI X, XUE F
  • 专利权人:   UNIV SOUTHEAST
  • 国际专利分类:   A61L031/02, A61L031/12, A61L031/14, A61L031/16, C25D011/30, C25D013/02, C25D015/00
  • 专利详细信息:   CN103768663-A 07 May 2014 A61L-031/12 201455 Pages: 7 Chinese
  • 申请详细信息:   CN103768663-A CN10007098 07 Jan 2014
  • 优先权号:   CN10007098

▎ 摘  要

NOVELTY - Long-acting antibacterial-type absorbable orthopedic device material comprises macro-molecule polymer for absorbing orthopedic device material, reinforced-toughening graphene with dispersively distributed polymer, and a biodegradable carrier material loaded with silver ion component. The method comprises e.g. performing hot pressure molding process, and performing slow release process of silver ions under antibacterial-antiinflammatory action, where carrier material of surface includes hydroxyapatite phase of porous ceramic layer of pure magnesium or magnesium alloy wire or sheet. USE - Used as a long-acting antibacterial-type absorbable orthopedic device material. DETAILED DESCRIPTION - Long-acting antibacterial-type absorbable orthopedic device material comprises macro-molecule polymer for absorbing orthopedic device material, reinforced-toughening graphene with dispersively distributed polymer, and a biodegradable carrier material loaded with silver ion component. The method comprises performing hot pressure molding process, and performing slow release process of silver ions under antibacterial-antiinflammatory action, where the carrier material of surface includes hydroxyapatite phase of porous ceramic layer made of pure magnesium or magnesium alloy wire or sheet composition, and then performing electrophoresis-double load micro-arc oxidation method with chemically impregnated ion exchange reaction method to obtain composite silver ion supported on the carrier material, where the volume fraction of the carrier material is 10-75%, the pore size of surface porous ceramic layer, is 1-50 mu m, layer thickness is 1-100 mu m, the amount of graphene is 0.01-5 vol.%, and the medical absorbable macro-molecule polymer (remaining amount). An INDEPENDENT CLAIM is also included for preparing the material, comprising (i) processing biodegradable carrier material by drawing the carrier material of pure magnesium or magnesium alloy, rolling or extruding to obtain wires or plates; (ii) adding the prepared silver iodide colloid solution into nano-powder micro-arc oxidation alkaline electrolyte containing hydroxyapatite, and performing electrophoresis-micro-arc oxidation by preliminary loading silver-ion into carrier material for pure magnesium or magnesium alloy wire or plate, where the electrophoresis-micro-arc oxidation voltage is 100-600 V, and the processing time is 2-60 minutes; (iii) taking the performing electrophoresis-micro-arc oxidation by preliminary loaded silver-ion or magnesium alloy wire or sheet material impregnated into the carrier containing silver nitrate solution having concentration of 5x 10-3- 2x 10-1 mol/l, and placing the mixture in a water bath at 20-100 degrees C, where the impregnation time is 0.5-48 hours, and performing chemical impregnation by ion exchange reaction of secondary loaded silver ion; and (iv) dissolving an organic solvent or performing high temperature melting and molding of polymer slurry and graphene which are uniformly mixed to obtain mixed slurry, impregnating or coating silver ion loaded with carrier material composite made of prefabricated blank, or loading the carrier material with silver ion arranged in a mold cavity, and injecting the mixed slurry, then performing hot pressing process, extruding, performing injection molding or drawing, and processing by molding into bar or plate, and then processing by machining into required structure of orthopedic device.