▎ 摘　　要

NOVELTY - Formation of core-shell nanohybrids involves providing nanoparticles (N1) and nanoparticles (N2) in a liquid medium at a pH, in which the nanoparticles (N1) are neutral and nanoparticles (N2) are negatively or positively charged, allowing the nanoparticles (N1) to homoaggregate, forming a core of at least one of the nanoparticles (N1), and allowing the nanoparticles (N2) to heteroaggregate with the homoaggregated nanoparticles (N1) to form shell on the core to provide the core-shell nanohybrids. USE - Formation of core-shell nanohybrids (claimed) used in catalytic oxidation and reduction, photocatalysis, environmental remediation, biosensors, bioimaging, and drug delivery. ADVANTAGE - The method is environmentally-friendly, simple, and economical. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for nanohybrid, which comprises core comprising at least one neutral nanoparticle in a shell comprising charged nanoparticles, and shell comprising nanogaps configured to allow access of substrates to the core.